Total synthesis and stereochemistry assignment of 15-membered peptide alkaloids abyssenine B and mucronine E
作者:Jing Wang、Lutz Schaeffler、Gang He、Dawei Ma
DOI:10.1016/j.tetlet.2007.07.142
日期:2007.9
The totalsynthesis of 15-membered peptide alkaloids abyssenine B and mucronine E was accomplished via olefination of phenylalanine-embodied aldehydes followed by CuI/N,N-dimethylglycine-catalyzed coupling of vinyl iodides with amides and FDPP-mediated macrocyclization in the key steps. From the totalsynthesis the stereochemistry of these two natural products was tentatively assigned to be S,S,S.