1-phenoxycarbonylimidazole | 30746-56-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-phenoxycarbonylimidazole
• 英文别名: 1-(Phenoxycarbonyl)-imidazol；Phenyl 1H-imidazole-1-carboxylate；phenyl imidazole-1-carboxylate
• CAS: 30746-56-6
• 化学式: C₁₀H₈N₂O₂
• 分子量: 188.186
• InChiKey: HJKIXOOCJJCFDM-UHFFFAOYSA-N

物化性质

• 熔点：
  57-60 °C
• 沸点：
  333.7±25.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-phenoxycarbonylimidazole 、 对溴苯乙酸 以 乙腈 为溶剂， 反应 24.0h， 生成 Phenyl 2-(4-bromophenyl)acetate
  参考文献：
  名称：

  On the reactivity of imidazole carbamates and ureas and their use as esterification and amidation reagents

  摘要：

  The optimization, substrate scope, and mechanism of esterification and amidation of carboxylic acids mediated by imidazole-based reagents are discussed. The innate reactivity of carbonylimidazole reagents with a range of nucleophiles is also explored. New reagents developed for the synthesis of alpha,beta-unsaturated esters are described, as are reagents for the preparation of tertiary amides directly from carboxylic acids. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.09.057
• 作为产物：
  描述：

  咪唑 、 氯甲酸苯酯 生成 1-phenoxycarbonylimidazole
  参考文献：
  名称：

  On the reactivity of imidazole carbamates and ureas and their use as esterification and amidation reagents

  摘要：

  The optimization, substrate scope, and mechanism of esterification and amidation of carboxylic acids mediated by imidazole-based reagents are discussed. The innate reactivity of carbonylimidazole reagents with a range of nucleophiles is also explored. New reagents developed for the synthesis of alpha,beta-unsaturated esters are described, as are reagents for the preparation of tertiary amides directly from carboxylic acids. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.09.057

文献信息

• A versatile method for preparation of O-alkylperoxycarbonic acids: epoxidation with alkyloxycarbonylimidazoles and hydrogen peroxide
  作者：Youko Tsunokawa、Shigeo Iwasaki、Shigenobu Okuda

  DOI：10.1016/s0040-4039(00)87275-5

  日期：1982.1

  A variety of O-alkylperoxycarbonic acids () were conveniently prepared by utilizing alkyloxycarbonylimidazoles () as their precursors. Epoxidation of alkenes with such peroxy-acids was studied and their reactivities were compared with those of peroxycarboxylic acids.

  通过使用烷氧基羰基咪唑（）作为前体可方便地制备各种O-烷基过氧碳酸（）。研究了用这种过氧酸对烯烃的环氧化，并将其反应性与过氧羧酸的反应性进行了比较。
• [EN] METHODS AND COMPOSITIONS FOR STUDYING, IMAGING, AND TREATING PAIN<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR ÉTUDIER, VISUALISER PAR IMAGERIE ET TRAITER LA DOULEUR
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2010129864A9

  公开（公告）日：2012-03-08
• Allylation of N-Acyl Quaternary Salts of Azaaromatics with Allyltrimethylsilane in the Presence of Triflate Ion
  作者：Akio Ohsawa、Takashi Itoh、Michiko Miyazaki、Kazuhiro Nagata

  DOI：10.3987/com-98-s32

  日期：——
• KISO, JOSIXISA;XAYASI, TEHTSUO
  作者：KISO, JOSIXISA、XAYASI, TEHTSUO

  DOI：——

  日期：——
• TSUNOKAWA, YOUKO;IWASAKI, SHIGEO;OKUDA, SHIGENOBU, TETRAHEDRON LETT., 1982, 23, N 20, 2113-2116
  作者：TSUNOKAWA, YOUKO、IWASAKI, SHIGEO、OKUDA, SHIGENOBU

  DOI：——

  日期：——