5-(3-Methylbut-1-ynyl)pyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-(3-Methylbut-1-ynyl)pyrimidine
• 英文别名: 5-(3-methylbut-1-ynyl)pyrimidine
• 化学式: C₉H₁₀N₂
• 分子量: 146.19
• InChiKey: RPJTXUDIPOWWEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• THERAPEUTIC COMPOUNDS
  申请人：Gilead Sciences, Inc.

  公开号：US20160083368A1

  公开（公告）日：2016-03-24

  Compounds of formula I: or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

  本发明揭示了化学式I的化合物或其盐。本发明还揭示了包括化合物I的药物组合物，制备化合物I的方法，用于制备化合物I的中间体以及治疗Retroviridae病毒感染，包括HIV病毒感染的治疗方法。
• Compounds and methods for CDK8 modulation and indications therefor
  申请人：Plexxikon Inc.

  公开号：US10703757B2

  公开（公告）日：2020-07-07

  Disclosed are compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein R4, X3, X4, X5, X6, X7 and Ring A are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.

  公开了式 I 的化合物： 或其药学上可接受的盐、溶解物、同分异构体、异构体或氚代类似物，其中 R4、X3、X4、X5、X6、X7 和环 A 如本公开所述的任一实施方案中所述；其组合物；及其用途。
• ARYL, HETEROARYL, AND HETEROCYCLIC COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：EP3110418B1

  公开（公告）日：2019-11-06
• US20140274884A1
  申请人：——

  公开号：US20140274884A1

  公开（公告）日：2014-09-18
• INHIBITORS OF HEPATITIS C VIRUS
  申请人：Gilead Sciences, Inc.

  公开号：US20150175655A1

  公开（公告）日：2015-06-25

  Compounds of Formula I are disclosed, As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.