N-[(2-chlorophenyl)methyl]-2-methyl-1-(3-methylphenyl)benzimidazole-5-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-[(2-chlorophenyl)methyl]-2-methyl-1-(3-methylphenyl)benzimidazole-5-carboxamide
• 化学式: C₂₃H₂₀ClN₃O
• 分子量: 389.9
• InChiKey: LDAVPBCDBBOHHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• US9790188B2
  申请人：——

  公开号：US9790188B2

  公开（公告）日：2017-10-17
• [EN] BENZIMIDAZOLE DERIVATIVES AND USES THEREOF<br/>[FR] DERIVES DE BENZIMIDAZOLE ET LEURS UTILISATIONS
  申请人：WHITEHEAD BIOMEDICAL INST

  公开号：WO2014145887A1

  公开（公告）日：2014-09-18

  The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and pharmaceutical compositions thereof. The present invention also provides methods and kits using the inventive compounds and pharmaceutical compositions for treating and/or preventing diseases associated with protein aggregation, such as amyloidoses (e.g., Parkinson's disease and Alzheimer's disease), treating and/or preventing neurodegenerative diseases, treating and/or preventing diseases associated with Tar DNA binding protein 43 kDa, reducing or preventing protein aggregation, and/or modulating E3 ubiquitin ligase in a subject in need thereof.