4-[(2,6-dimethylpyridin-3-yl)methylamino]-6-[(3S)-3-(5-methoxypyridin-2-yl)-2-methylbutoxy]-2-methylpyridazin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-[(2,6-dimethylpyridin-3-yl)methylamino]-6-[(3S)-3-(5-methoxypyridin-2-yl)-2-methylbutoxy]-2-methylpyridazin-3-one
• 化学式: C₂₄H₃₁N₅O₃
• 分子量: 437.5
• InChiKey: UTFDTSITTRZFJT-LWKPJOBUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  88.9
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] SUBSTITUTED PYRIDIZINONE DERIVATIVES AS PDE10 INHIBITORS<br/>[FR] DÉRIVÉS DE PYRIDIZINONE SUBSTITUÉS UTILISÉS EN TANT QU'INHIBITEURS DE LA PDE10
  申请人：MERCK SHARP & DOHME

  公开号：WO2014139150A1

  公开（公告）日：2014-09-18

  The present invention is directed to substituted pyridizinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

  本发明涉及一种具有式（I）的取代吡啶酮化合物，其可用作治疗与磷酸二酯酶10（PDE10）相关的中枢神经系统疾病的治疗剂。本发明还涉及利用这种化合物治疗神经学和精神疾病，如精神分裂症、精神病或亨廷顿病，以及与纹状体功能不足或基底节功能障碍相关的疾病。
• [EN] SUBSTITUTED PYRIDIZINONE DERIVATIVES AS PDE10 INHIBITORS<br/>[FR] DÉRIVÉS DE PYRIDIZINONE SUBSTITUÉS EN TANT QU'INHIBITEURS DE PDE10
  申请人：MERCK SHARP & DOHME

  公开号：WO2014150114A1

  公开（公告）日：2014-09-25

  The present invention is directed to substituted pyridizinone compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.