US9688672, Example 398

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: US9688672, Example 398
• 英文别名: (4R)-3-[2-[[(1S)-1-[5-(4-chlorophenyl)-1,2-oxazol-3-yl]ethyl]amino]-5-fluoropyrimidin-4-yl]-4-[(1R)-1-fluoroethyl]-1,3-oxazolidin-2-one
• 化学式: C₂₀H₁₈ClF₂N₅O₃
• 分子量: 449.8
• InChiKey: KPUWPLMVSGVTML-OHUAYANFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  93.4
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• US20140275083A1
  申请人：——

  公开号：US20140275083A1

  公开（公告）日：2014-09-18
• 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH
  申请人：CAFERRO Thomas Raymond

  公开号：US20160318915A1

  公开（公告）日：2016-11-03

  The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2a , R 2b and R 3 -R 7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
• US9688672B2
  申请人：——

  公开号：US9688672B2

  公开（公告）日：2017-06-27