6-Methyl-3-phenyl-4-pyridin-4-ylpyridazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-Methyl-3-phenyl-4-pyridin-4-ylpyridazine
• 英文别名: 6-methyl-3-phenyl-4-pyridin-4-ylpyridazine
• 化学式: C₁₆H₁₃N₃
• 分子量: 247.29
• InChiKey: PJHOJGXIWWZORZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• MAP KINASE MODULATORS AND USES THEREOF
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20160130253A1

  公开（公告）日：2016-05-12

  The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38α MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments, the disease is Alzheimer's Disease, ALS, Huntington's Disease or Parkinson's Disease.

  本发明提供了新型的MAP激酶抑制剂和包含它们的组合物。在某些实施例中，MAP激酶抑制剂是p38α MAP激酶抑制剂。该发明还提供了治疗疾病的方法，包括给予MAP激酶抑制剂或包含MAP激酶抑制剂的组合物。在某些实施例中，该疾病是阿尔茨海默病，肌萎缩性侧索硬化症，亨廷顿病或帕金森病。
• MAP kinase modulators and uses thereof
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US10428047B2

  公开（公告）日：2019-10-01

  The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38α MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments, the disease is Alzheimer's Disease, ALS, Huntington's Disease or Parkinson's Disease.

  本发明提供了新型 MAP 激酶抑制剂和包含这些抑制剂的组合物。在某些实施方案中，MAP 激酶抑制剂是 p38α MAP 激酶抑制剂。本发明进一步提供了治疗疾病的方法，包括施用 MAP 激酶抑制剂或包含 MAP 激酶抑制剂的组合物。在某些实施方案中，疾病是阿尔茨海默病、渐冻人症、亨廷顿氏病或帕金森氏病。
• US9783525B2
  申请人：——

  公开号：US9783525B2

  公开（公告）日：2017-10-10
• [EN] MAP KINASE MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS DE MAP KINASE ET UTILISATIONS DE CEUX-CI
  申请人：UNIV COLUMBIA

  公开号：WO2014145485A2

  公开（公告）日：2014-09-18

  The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38a MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments, the disease is Alzheimer's Disease, ALS, Huntington's Disease or Parkinson's Disease.