3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine;1-[4-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy]-3-methoxyphenyl]ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine;1-[4-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy]-3-methoxyphenyl]ethanone
• 化学式: C43H51FN4O4
• 分子量: 706.9
• InChiKey: QZNLAIIBSYDSKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  52
• 可旋转键数：
  12
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  71.3
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• CRANIAL DELIVERY OF PHARMACEUTICALS
  申请人：Glia LLC

  公开号：EP2968368A2

  公开（公告）日：2016-01-20
• [EN] CRANIAL DELIVERY OF PHARMACEUTICALS<br/>[FR] ADMINISTRATION CRÂNIENNE DE SUBSTANCES PHARMACEUTIQUES
  申请人：GLIA LLC

  公开号：WO2014152385A2

  公开（公告）日：2014-09-25

  A method for rapid delivery of an active compound to innervate a cranial nerve of a subject. Also provided is a method for treating a disease or condition by topically applying a pharmaceutical composition to the face excluding the palpebral part of the eye, in an amount effective for treating the disease or condition.