4-(Dimethylamino)-2-(propylamino)pyrimido[5,4-d]pyrimidine-8-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-(Dimethylamino)-2-(propylamino)pyrimido[5,4-d]pyrimidine-8-carboxylic acid
• 英文别名: 4-(dimethylamino)-2-(propylamino)pyrimido[5,4-d]pyrimidine-8-carboxylic acid
• 化学式: C₁₂H₁₆N₆O₂
• 分子量: 276.29
• InChiKey: LWFYVPSGIXQIKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• NOVEL BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME
  申请人：Galleon Pharmaceuticals, Inc.

  公开号：EP2968329A1

  公开（公告）日：2016-01-20
• [EN] NOVEL BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME<br/>[FR] NOUVEAUX COMPOSÉS DE MODULATION DU CONTRÔLE DE LA RESPIRATION ET LEURS PROCÉDÉS D'UTILISATION
  申请人：GALLEON PHARMACEUTICALS INC

  公开号：WO2014151462A1

  公开（公告）日：2014-09-25

  The present invention includes pyrimido[5,4-d]pyrimidines that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of the invention.