4-(chloromethyl)-6,8-difluoro-7-[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4-(chloromethyl)-6,8-difluoro-7-[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one
• 化学式: C₁₆H₁₅ClF₂O₈
• 分子量: 408.73
• InChiKey: ATTAHAWLQLRXSU-FQTOMSAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• STERILIZATION INDICATOR INCLUDING A SIMPLIFIED GENETICALLY ENGINEERED BIOLOGICAL INDICATOR
  申请人：American Sterilizer Company

  公开号：EP2970992A1

  公开（公告）日：2016-01-20
• BIOLOGICAL INDICATOR
  申请人：American Sterilizer Company

  公开号：EP3206723A1

  公开（公告）日：2017-08-23
• [EN] STERILIZATION INDICATOR INCLUDING A SIMPLIFIED GENETICALLY ENGINEERED BIOLOGICAL INDICATOR<br/>[FR] INDICATEUR DE STÉRILISATION INCLUANT UN INDICATEUR BIOLOGIQUE SIMPLIFIÉ GÉNÉTIQUEMENT MODIFIÉ
  申请人：AMERICAN STERILIZER CO

  公开号：WO2014149379A1

  公开（公告）日：2014-09-25

  A sterilization indicator, including a first compartment containing a genetically engineered biological indicator, and a second compartment containing an enzyme substrate, the second compartment adapted to maintain the enzyme substrate separate from the biological indicator during sterilization, and to permit the enzyme substrate to contact the biological indicator after the biological indicator has been exposed to the sterilization medium; in which the genetically engineered biological indicator comprises at least one test organism and at least one reporter gene suitable for producing an indicator enzyme, the reporter gene being taken up by the test organism; and the test organism is free of any active or activatable repressor gene that would inhibit expression of the reporter gene if present in the test organism or sterilization indicator, and the indicator enzyme and the enzyme substrate are selected such that enzymatic action of the indicator enzyme upon the enzyme substrate yields a detectable signal.
• [EN] BIOLOGICAL INDICATOR<br/>[FR] INDICATEUR BIOLOGIQUE
  申请人：AMERICAN STERILIZER CO

  公开号：WO2016060714A1

  公开（公告）日：2016-04-21

  This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.