2-Oxochromene-3-carbaldehyde;thiophene

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 2-Oxochromene-3-carbaldehyde;thiophene
• 英文别名: 2-oxochromene-3-carbaldehyde;thiophene
• 化学式: C14H10O3S
• 分子量: 258.29
• InChiKey: GDJLZSURUQWHNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.35
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• A Fluorescent Chemical Sensor for Biological Amines
  申请人：THE CURATORS OF THE UNIVERSITY OF MISSOURI

  公开号：US20160274091A1

  公开（公告）日：2016-09-22

  The invention is provides for a variety of fluorescence sensing compounds characterized generally as having a coumarin-3-aldehyde scaffold with a pendant aryl moiety at the C4-position of the scaffold. The further provides a method for detecting primary amines in a biological sample using said compounds. Especially, for the selective labeling and imaging of catecholamines in live and fixed secretory cells.

  该发明提供了一种多种荧光感应化合物，通常表征为具有香豆素-3-醛骨架的化合物，其中在骨架的C4位置具有一个芳基基团。进一步提供了一种使用这些化合物在生物样本中检测初级胺的方法。特别适用于对活体和固定分泌细胞中儿茶酚胺进行选择性标记和成像。
• Fluorescent chemical sensor for biological amines
  申请人：The Curators of the University of Missouri

  公开号：US10330673B2

  公开（公告）日：2019-06-25

  The invention is provides for a variety of fluorescence sensing compounds characterized generally as having a coumarin-3-aldehyde scaffold with a pendant aryl moiety at the C4-position of the scaffold. The further provides a method for detecting primary amines in a biological sample using said compounds. Especially, for the selective labeling and imaging of catecholamines in live and fixed secretory cells.

  本发明提供了多种荧光传感化合物，其一般特征是具有香豆素-3-醛支架，并在支架的 C4 位上具有一个垂挂芳基。本发明还提供了一种使用上述化合物检测生物样品中伯胺的方法。特别是用于活细胞和固定分泌细胞中儿茶酚胺的选择性标记和成像。
• [EN] A FLUORESCENT CHEMICAL SENSOR FOR BIOLOGICAL AMINES<br/>[FR] CAPTEUR CHIMIQUE FLUORESCENT POUR DES AMINES BIOLOGIQUES
  申请人：UNIV MISSOURI

  公开号：WO2014153533A1

  公开（公告）日：2014-09-25

  The invention is provides for a variety of fluorescence sensing compounds characterized generally as having a coumarin-3-aldehyde scaffold with a pendant aryl moiety at the C4-position of the scaffold. The further provides a method for detecting primary amines in a biological sample using said compounds. Especially, for the selective labeling and imaging of catecholamines in live and fixed secretory cells.