Uridine 5-diphosphoglucose disodium salt

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: Uridine 5-diphosphoglucose disodium salt
• 英文别名: disodium;[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[(2R,3S,4S,5R)-1,3,4,5-tetrahydroxy-6-oxohexan-2-yl]oxyphosphoryl] phosphate
• 化学式: C15H22N2Na2O17P2
• 分子量: 610.27
• InChiKey: KTRYLHOLECXBCD-VLQZIUFZSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -12.21
• 重原子数：
  38
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  305
• 氢给体数：
  7
• 氢受体数：
  17

文献信息

• [EN] MODIFIED INDOLE ALKALOIDS FOR THERAPEUTIC USES<br/>[FR] ALCALOÏDES INDOLIQUES MODIFIÉS POUR UTILISATIONS THÉRAPEUTIQUES
  申请人：NEW ATLAS BIOTECHNOLOGIES INC

  公开号：WO2022133314A1

  公开（公告）日：2022-06-23

  Disclosed herein are enzymatic and modified host cell methods for prepared modified indole alkaloids. Also disclosed herein are modified indole alkaloids and their therapeutic use for treating diseases and disorders.

  本文披露了制备改性吲哚生物碱的酶和改性宿主细胞方法。本文还披露了改性吲哚生物碱及其治疗用于治疗疾病和疾病的方法。
• Compositions and methods for detecting and/or treating inflammation
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：US10088489B2

  公开（公告）日：2018-10-02

  The present disclosure relates to assays and methods for the detection of renal inflammation by measuring the level of P2Y14 and/or UDP-glucose in a sample from a subject, such as a urine sample. The present disclosure also relates to methods for the treatment of renal inflammation by administering a P2Y14 inhibitor.

  本公开涉及通过测量受试者样本（如尿样）中的 P2Y14 和/或 UDP-葡萄糖水平来检测肾脏炎症的检测方法。本公开还涉及通过施用 P2Y14 抑制剂治疗肾脏炎症的方法。
• COMPOSITIONS AND METHODS FOR DETECTING AND/OR TREATING INFLAMMATION
  申请人：The General Hospital Corporation

  公开号：EP3066472B1

  公开（公告）日：2019-07-31
• US9891236B2
  申请人：——

  公开号：US9891236B2

  公开（公告）日：2018-02-13
• [EN] COMPOSITIONS AND METHODS FOR DETECTING AND/OR TREATING INFLAMMATION<br/>[FR] COMPOSITIONS ET MÉTHODES POUR LA DÉTECTION ET/OU LE TRAITEMENT D'UNE INFLAMMATION
  申请人：GEN HOSPITAL CORP

  公开号：WO2015070001A2

  公开（公告）日：2015-05-14

  The present disclosure relates to assays and methods for the detection of renal inflammation by measuring the level of P2Y14 and/or UDP-glucose in a sample from a subject, such as a urine sample. The present disclosure also relates to methods for the treatment of renal inflammation by administering a P2Y14 inhibitor.