3,5-bis(trifluoromethyl)benzyl-1-sulfonyl chloride | 400770-85-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-bis(trifluoromethyl)benzyl-1-sulfonyl chloride
• 英文别名: [3,5-bis(trifluoromethyl)phenyl]methanesulfonyl Chloride
• CAS: 400770-85-6
• 化学式: C₉H₅ClF₆O₂S
• mdl: MFCD01862555
• 分子量: 326.647
• InChiKey: XLLFBEQKESGDJW-UHFFFAOYSA-N

物化性质

• 沸点：
  260.7±40.0 °C(Predicted)
• 密度：
  1.591±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  3,5-bis(trifluoromethyl)benzyl-1-sulfonyl chloride 在 吡啶 、 碳酸氢钠 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 4.0h， 生成 3-(3,5-bis(trifluoromethyl)phenylsulfonamido)propyl methanesulfonate
  参考文献：
  名称：

  3,5-Bis(trifluoromethyl)phenylsulfonamides, a novel pancreatic cancer active lead. Investigation of the terminal aromatic moiety

  摘要：

  DOI：

  10.1016/j.bmcl.2022.128591

文献信息

• [EN] REVERSE-TURN MIMETICS AND COMPOSITION AND METHODS RELATING THERETO<br/>[FR] MIMETIQUES A ROTATION INVERSE, COMPOSITION ET TECHNIQUES ASSOCIEES
  申请人：MYRIAD GENETICS INC

  公开号：WO2004035587A1

  公开（公告）日：2004-04-29

  Reverse-turn mimetics and methods relating to the same having Structure (I) are disclosed, including pharmaceutically acceptable salts and stereoisomers thereof, wherein R1, R2, R3 and R4 are as defined herein. Such compounds have utility over a wide range of applications, including use as diagnostic and therapeutic agents. In particular, compounds of this invention, and pharmaceutical compositions containing such compounds, are neurokinin (tachykinin) antagonists. Libraries containing the reverse-turn mimetics of this invention are also disclosed.

  本发明揭示了具有结构（I）的反转环拟物及其相关方法，包括其药学上可接受的盐和立体异构体，其中R1、R2、R3和R4如本文所定义。这些化合物具有广泛的应用，包括用作诊断和治疗剂。特别地，本发明的化合物和含有这些化合物的制药组合物是神经激肽（速激肽）拮抗剂。本发明还揭示了含有这种反转环拟物的文库。
• Chemical compounds
  申请人：Adams Leroy Jerry

  公开号：US20050004142A1

  公开（公告）日：2005-01-06

  Furo- and thienopyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such furo- and thienopyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

  本文描述了作为TIE-2和/或VEGFR-2抑制剂有用的呋喃和噻吩嘧啶衍生物。所述发明还包括制备这种呋喃和噻吩嘧啶衍生物的方法，以及使用它们治疗增殖过度性疾病的方法。
• Production processes and systems, compositions, surfactants, monomer units, metal complexes, phosphate esters, glycols, aqueous film forming foams, and foams stabilizers
  申请人：Boggs Janet

  公开号：US20070149437A1

  公开（公告）日：2007-06-28

  Production processes and systems are provided that include reacting halogenated compounds, dehalogenating compounds, reacting alcohols, reacting olefins and a saturated compounds, reacting reactants having at least two —CF 3 groups with reactants having cyclic groups. RF compositions such as R F -intermediates, R F -surfactants, R F -monomers, R F- monomer units, R F -metal complexes, R F -phosphate esters, R F -glycols, R F urethanes, and/or R F -foam stabilizers. The R F portion can include at least two —CF 3 groups, at least three —CF 3 groups, and/or at least two —CF 3 groups and at least two —CH 2 — groups. Detergents, emulsifiers, paints, adhesives, inks, wetting agents, foamers, and defoamers including the R F -surfactant composition are provided. Acrylics, resins, and polymers are provided that include a R F -monomer unit Compositions are provided that include a substrate having a R F -composition thereover. Aqueous Film Forming Foam (“AFFF”) formulations are provided that can include R F -surfactants and/or R F -foam stabilizers are provided.

  提供生产过程和系统，包括反应卤代化合物，脱卤化合物，反应醇，反应烯烃和饱和化合物，将至少含有两个—CF3基团的反应物与具有环状基团的反应物反应。提供RF组分，例如RF中间体，RF表面活性剂，RF单体，RF单体单元，RF金属络合物，RF磷酸酯，RF乙二醇，RF聚氨酯和/或RF泡沫稳定剂。RF部分可以包括至少两个—CF3基团，至少三个—CF3基团，和/或至少两个—CF3基团和至少两个—CH2—基团。提供包括RF表面活性剂组分的清洁剂，乳化剂，油漆，粘合剂，油墨，润湿剂，发泡剂和消泡剂。提供包括RF单体单元的丙烯酸，树脂和聚合物。提供包括具有RF组分的基底的组合物。提供包括RF表面活性剂和/或RF泡沫稳定剂的水性成膜泡沫（“AFFF”）配方。
• Production processes and systems, compositions, surfactants, monomer units, metal complexes, phosphate esters, glycols, aqueous film forming foams and foam stabilizers
  申请人：Boggs Janet

  公开号：US20070161537A1

  公开（公告）日：2007-07-12

  Production processes and systems are provided that include reacting halogenated compounds, dehalogenating compounds, reacting alcohols, reacting olefins and a saturated compounds, reacting reactants having at least two —CF 3 groups with reactants having cyclic groups. R F -compositions such as R F -intermediates, R F -surfactants, R F monomers, R F -monomer units, R F -metal complexes, R F -phosphate esters, R F -glycols, R F -urethanes, and/or R F -foam stabilizers. The R F portion can include at least two CF 3 groups, at least three —CF 3 groups, and/or at least two —CF 3 groups and at least two —CH 2 — groups. Detergents, emulsifiers, paints, adhesives, inks, wetting agents, foamers, and defoamers including the R F -surfactant composition are provided. Acrylics, resins, and polymers are provided that include a R F -monomer unit. Compositions are provided that include a substrate having a R F -composition thereover. Aqueous Film Forming Foam (“AFFF”) formulations are provided that can include R F surfactants and/or R F -foam stabilizers are provided.

  提供了生产过程和系统，其中包括反应卤代化合物，去卤化化合物，反应醇，反应烯烃和饱和化合物，反应至少有两个—CF3基团的反应物与具有环状基团的反应物反应。提供了RF组分，例如RF中间体，RF表面活性剂，RF单体，RF单体单元，RF金属配合物，RF磷酸酯，RF乙二醇，RF聚氨酯和/或RF泡沫稳定剂。RF部分可以包括至少两个CF3基团，至少三个—CF3基团，以及至少两个—CF3基团和至少两个—CH2—基团。提供了包括RF表面活性剂组分的洗涤剂、乳化剂、油漆、粘合剂、油墨、润湿剂、起泡剂和消泡剂。提供了包括RF单体单元的丙烯酸、树脂和聚合物。提供了包括具有RF组分的基底的组合物。提供了可以包括RF表面活性剂和/或RF泡沫稳定剂的水性成膜泡沫（“AFFF”）配方。
• Production Processes and Systems, Compositions, Surfactants, Monomer Units, Metal Complexes, Phosphate Esters, Glycols, Aqueous Film Foams, and Foam Stabilizers
  申请人：Boggs Janet

  公开号：US20070282115A1

  公开（公告）日：2007-12-06

  Production processes and systems are provided that include reacting halogenated compounds, dehalogenating compounds, reacting alcohols, reacting olefins and a saturated compounds, reacting reactants having at least two —CF 3 groups with reactants having cyclic groups. R F -compositions such as R F -intermediates, R F -surfactants, R F -monomers, R F -monomer units, R F -metal complexes, R F -phosphate esters, R F -glycols, R F -urethanes, and/or R F -foam stabilizers. The R F portion can include at least two —CF 3 groups, at least three —CF 3 groups, and/or at least two —CF 3 groups and at least two —CH 2 — groups. Detergents, emulsifiers, paints, adhesives, inks, wetting agents, foamers, and defoamers including the R F -surfactant composition are provided. Acrylics, resins, and polymers are provided that include a R F -monomer unit. Compositions are provided that include a substrate having a R F -composition thereover. Aqueous Film Forming Foam (“AFFF”) formulations are provided that can include R F -surfactants and/or R F -foam stabilizers are provided.

  提供了包括反应卤代化合物、脱卤化合物、反应醇、反应烯烃和饱和化合物、反应至少具有两个-CF3基团的反应物与具有环状基团的反应物的生产过程和系统。提供了RF组分，例如RF中间体、RF表面活性剂、RF单体、RF单体单元、RF金属配合物、RF磷酸酯、RF乙二醇、RF聚氨酯和/或RF泡沫稳定剂。RF部分可以包括至少两个-CF3基团、至少三个-CF3基团，以及至少两个-CF3基团和至少两个-CH2-基团。提供了包括RF表面活性剂组分的洗涤剂、乳化剂、油漆、粘合剂、油墨、润湿剂、起泡剂和消泡剂。提供了包括RF单体单元的丙烯酸、树脂和聚合物。提供了包括RF组分覆盖在基底上的组合物。提供了可以包括RF表面活性剂和/或RF泡沫稳定剂的水性成膜泡沫（“AFFF”）配方。