1,2,3,4-Tetrahydropyrido[1,2-a]benzimidazole-7-carboxamide | 1779133-55-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1,2,3,4-Tetrahydropyrido[1,2-a]benzimidazole-7-carboxamide
• 英文别名: 1,2,3,4-tetrahydropyrido[1,2-a]benzimidazole-7-carboxamide
• CAS: 1779133-55-9
• 化学式: C₁₂H₁₃N₃O
• 分子量: 215.25
• InChiKey: IXHVBLYBKXUYDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  60.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• COMPOUNDS FOR TREATING CERTAIN LEUKEMIAS
  申请人：Terns, Inc.

  公开号：EP3852745A2

  公开（公告）日：2021-07-28
• [EN] COMPOUNDS FOR TREATING CERTAIN LEUKEMIAS<br/>[FR] COMPOSÉS DESTINÉS AU TRAITEMENT DE CERTAINES LEUCÉMIES
  申请人：TERNS INC

  公开号：WO2020061086A2

  公开（公告）日：2020-03-26

  Provided herein are compounds, preferably compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, compositions thereof, and methods of their preparation, and methods of inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, and methods for treating diseases wherein modulation of BCR-ABL1 activity prevents, inhibits, or ameliorates the pathology and/or symptomology of the disease.