3-(2,4,6-trioxo-hexahydro-pyrimidin-5-yl)-propionic acid | 22384-33-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-(2,4,6-trioxo-hexahydro-pyrimidin-5-yl)-propionic acid
• 英文别名: 3-(2,4,6-trioxo-1,3-diazinan-5-yl)propanoic acid
• CAS: 22384-33-4
• 化学式: C₇H₈N₂O₅
• mdl: MFCD00609542
• 分子量: 200.151
• InChiKey: YARSJLGLRSDQOK-UHFFFAOYSA-N

物化性质

• 密度：
  1.463±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 危险等级：
  IRRITANT

文献信息

• Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
  申请人：The Johns Hopkins University

  公开号：US10568975B2

  公开（公告）日：2020-02-25

  Surface conjugated diamagnetic Chemical Exchange Saturation Transfer (diaCEST) agent carriers and methods of making and using are described herein. The particles are safe alternatives to conventional paramagnetic or superparamagnetic metal-based MRI contrast agents that are often toxic and therefore not biocompatible. The carriers described herein can provide simultaneous monitoring of multiple particle types labeled with ‘multicolor’ diaCEST contrast agents. In some embodiments, the carriers are micro- and/or nanoparticles. In other embodiments, the carriers are liposomes. In some embodiments, the particles and/or liposomes are mucus penetrating. In other embodiments, the particles and/or liposomes are not mucus penetrating.

  本文描述了表面共轭二磁性化学交换饱和转移（diaCEST）剂载体及其制造和使用方法。这些粒子是传统顺磁性或超顺磁性金属磁共振成像造影剂的安全替代品，而传统的顺磁性或超顺磁性金属磁共振成像造影剂通常具有毒性，因此不具有生物相容性。本文所述的载体可同时监测多种用 "多色 "DiaCEST 造影剂标记的粒子类型。在某些实施方案中，载体是微型和/或纳米颗粒。在其他实施方案中，载体是脂质体。在某些实施方案中，颗粒和/或脂质体具有粘液穿透性。在其他实施方案中，微粒和/或脂质体不具有粘液穿透性。
• NANOPARTICLES FOR MAGNETIC RESONANCE IMAGING TRACKING AND METHODS OF MAKING AND USING THEREOF
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US20160206760A1

  公开（公告）日：2016-07-21

  Surface conjugated diamagnetic Chemical Exchange Saturation Transfer (diaCEST) agent carriers and methods of making and using are described herein. The particles are safe alternatives to conventional paramagnetic or superparamagnetic metal-based MRI contrast agents that are often toxic and therefore not biocompatible. The carriers described herein can provide simultaneous monitoring of multiple particle types labeled with ‘multicolor’ diaCEST contrast agents. In some embodiments, the carriers are micro- and/or nanoparticles. In other embodiments, the carriers are liposomes. In some embodiments, the particles and/or liposomes are mucus penetrating. In other embodiments, the particles and/or liposomes are not mucus penetrating.