5-苯基喹喔啉 | 103150-99-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 5-苯基喹喔啉
• 英文名称: 5-Phenyl-chinoxalin
• 英文别名: 5-phenylquinoxaline
• CAS: 103150-99-8
• 化学式: C₁₄H₁₀N₂
• 分子量: 206.247
• InChiKey: ATLFXOGEMOSZPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氨基-3-硝基联苯 在 palladium on activated charcoal 、 乙醇 作用下， 生成 5-苯基喹喔啉
  参考文献：
  名称：

  573.合成一些苯基-cinnolines，-phthalazines和-quinoxalines

  摘要：

  DOI：

  10.1039/jr9590002858

文献信息

• Rh(III)-catalyzed C8 arylation of quinoline N-oxides with arylboronic acids
  作者：Yuanqiong Huang、Xueli Lv、Hongjian Song、Yuxiu Liu、Qingmin Wang

  DOI：10.1016/j.cclet.2019.11.028

  日期：2020.6

  Abstract Herein, we report the first RhIII-catalyzed regioselective C8 arylation of quinoline N-oxides with commercially available arylboronic acids as coupling partners. This procedure is simple, and the reaction shows perfect regioselectivity, a broad substrate scope, and isolated yields of up to 92%. We demonstrate the utility of the reaction by using it for late-stage functionalization of a fungicide

  摘要在本文中，我们报道了首次以RhIII催化的喹啉N-氧化物的RhoIII催化区域选择性C8芳基化，其以市售的芳基硼酸作为偶联伙伴。此过程很简单，反应显示出完美的区域选择性，广泛的底物范围，分离出的收率高达92％。通过将其用于杀真菌剂的后期功能化，我们证明了该反应的实用性。
• Compound for organic photoelectric device and organic photoelectric device including the same
  申请人：Jung Ho-Kuk

  公开号：US20100200054A1

  公开（公告）日：2010-08-12

  A compound for an organic photoelectric device, represented by the following Chemical Formula 1:

  一种用于有机光电器件的化合物，化学式如下：Chemical Formula 1
• Potassium <i>t</i>-Butoxide Alone Can Promote the Biaryl Coupling of Electron-Deficient Nitrogen Heterocycles and Haloarenes
  作者：Shuichi Yanagisawa、Kirika Ueda、Tadashi Taniguchi、Kenichiro Itami

  DOI：10.1021/ol8019764

  日期：2008.10.16

  The biaryl coupling of electron-deficient nitrogen heterocycles and haloarenes can be promoted by potassium t-butoxide alone, without the addition of any exogenous transition metal species. Electron-deficient nitrogen heterocycles such as pyridine, pyridazine, pyrimidine, pyrazine, and quinoxaline are arylated with haloarenes. Control experiments support a radical-based mechanism. Taking these findings

  缺电子的氮杂环和卤代芳烃的联芳基偶合可以通过单独的叔丁醇钾来促进，而无需添加任何外源过渡金属物质。电子不足的氮杂环（例如吡啶，哒嗪，嘧啶，吡嗪和喹喔啉）被卤代芳烃芳基化。对照实验支持基于根本的机制。考虑到这些发现，在高温或微波辐射下，使用叔丁醇盐碱和卤代芳烃的自由基过渡过程可能部分参与了报道的过渡金属催化的芳基化反应。
• Metal complexes with anticancer activity
  申请人：Bangalore Ramesh

  公开号：US20100209537A1

  公开（公告）日：2010-08-19

  This inventive subject matter relates to novel transitional metal complexes of Quinoxalines, methods for making such compounds, and methods for using such compounds for treating diseases and disorders mediated by kinase activity. The present invention relates to new substituted Quinoxaline compounds, their tautomers, stereoisomers, polymorphs, esters, metabolites, and prodrugs, to the pharmaceutically acceptable salts of the compounds, tautomers, stereoisomers, polymorphs, esters, metabolites, and prodrugs, to compositions of any of the aforementioned embodiments together with pharmaceutically acceptable carriers, and to uses of any of the aforementioned embodiments, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cancer.

  本发明涉及新型喹喔啉过渡金属配合物、制备这些化合物的方法，以及使用这些化合物治疗由激酶活性介导的疾病和疾病的方法。本发明涉及新的取代喹喔啉化合物、它们的互变异构体、立体异构体、多晶形、酯类、代谢物和前药，以及这些化合物、互变异构体、立体异构体、多晶形、酯类、代谢物和前药的药学上可接受的盐，任何上述实施例的组合物与药学上可接受的载体，以及任何上述实施例的用途，无论是单独使用还是与至少一种其他治疗剂联合使用，在预防或治疗癌症方面。
• COMPOUNDS FOR USE IN LIGHT EMITTING DEVICES
  申请人：Nitto Denko Corporation

  公开号：US20140061614A1

  公开（公告）日：2014-03-06

  Optionally substituted ambipolar naphthalene compounds useful in light-emitting devices are described, including without limitation 9-(3-(10-(3-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl)anthracen-9-yl)phenyl)-9H-carbazole and 9-(3-(10-(3-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl)anthracen-9-yl)phenyl)-9H-carbazole.

  本文描述了在发光装置中有用的可选替代的双极萘化合物，包括但不限于9-(3-(10-(3-(1-苯基-1H-苯并[d]咪唑-2-基)苯基)蒽-9-基)苯基)-9H-咔唑和9-(3-(10-(3-(1-苯基-1H-苯并[d]咪唑-2-基)苯基)蒽-9-基)苯基)-9H-咔唑。