[7-(diethylamino)-2-sulfanylidenechromen-4-yl]methyl N-[2-[4-[cyclohexylidene-(4-hydroxyphenyl)methyl]phenoxy]ethyl]carbamate | 1433222-52-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [7-(diethylamino)-2-sulfanylidenechromen-4-yl]methyl N-[2-[4-[cyclohexylidene-(4-hydroxyphenyl)methyl]phenoxy]ethyl]carbamate
• CAS: 1433222-52-6
• 化学式: C₃₆H₄₀N₂O₅S
• 分子量: 612.79
• InChiKey: UISCOOXDOFRXSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  44
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (7-(diethylamino)-2-oxo-2H-chromen-4-yl)methyl acetate 在 劳森试剂 、 盐酸 、 4-二甲氨基吡啶 作用下， 以 乙醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 47.0h， 生成 [7-(diethylamino)-2-sulfanylidenechromen-4-yl]methyl N-[2-[4-[cyclohexylidene-(4-hydroxyphenyl)methyl]phenoxy]ethyl]carbamate
  参考文献：
  名称：

  A Blue-Absorbing Photolabile Protecting Group for in Vivo Chromatically Orthogonal Photoactivation

  摘要：

  The small and synthetically easily accessible 7-diethylamino4-thiocoumarinylmethyl photolabile protecting group has been validated for uncaging with blue light. It exhibits a significant action cross-section for uncaging in the 470-500 nm wavelength range and a low light absorption between 350 and 400 nm. These attractive features have been implemented in living zebrafish embryos to perform chromatic orthogonal photoactivation of two biologically active species controlling biological development with UV and blue-cyan light sources, respectively.

  DOI：

  10.1021/cb400178m

文献信息

• A Blue-Absorbing Photolabile Protecting Group for <i>in Vivo</i> Chromatically Orthogonal Photoactivation
  作者：Ludovic Fournier、Carole Gauron、Lijun Xu、Isabelle Aujard、Thomas Le Saux、Nathalie Gagey-Eilstein、Sylvie Maurin、Sylvie Dubruille、Jean-Bernard Baudin、David Bensimon、Michel Volovitch、Sophie Vriz、Ludovic Jullien

  DOI：10.1021/cb400178m

  日期：2013.7.19

  The small and synthetically easily accessible 7-diethylamino4-thiocoumarinylmethyl photolabile protecting group has been validated for uncaging with blue light. It exhibits a significant action cross-section for uncaging in the 470-500 nm wavelength range and a low light absorption between 350 and 400 nm. These attractive features have been implemented in living zebrafish embryos to perform chromatic orthogonal photoactivation of two biologically active species controlling biological development with UV and blue-cyan light sources, respectively.