N-(methylcarbamoyl)benzenesulfonamide | 52102-38-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(methylcarbamoyl)benzenesulfonamide
• 英文别名: 1-Methyl-3-phenylsulfonyl-urea；N-Methyl-N'-phenylsulfonylharnstoff；N-benzenesulfonyl-N'-methyl-urea；N-Benzolsulfonyl-N'-methyl-harnstoff；N-phenylsulphonyl-N'-methylurea；1-(Benzenesulfonyl)-3-methylurea
• CAS: 52102-38-2
• 化学式: C₈H₁₀N₂O₃S
• 分子量: 214.245
• InChiKey: ZRERKMQKMINGSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯磺酰胺单钠盐 在 sodium hydroxide 、 双氧水 作用下， 生成 N-(methylcarbamoyl)benzenesulfonamide
  参考文献：
  名称：

  Onisi, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1959, vol. 79, p. 559,564

  摘要：

  DOI：

文献信息

• Monosaccharide Derivatives as Anti-Inflammatory and/or Anti-Cancer Agents
  申请人：Sattigeri Vishwajanani Jitendra

  公开号：US20090048186A1

  公开（公告）日：2009-02-19

  The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

  本发明涉及单糖衍生物作为抗炎剂。本发明的化合物可用于抑制和预防炎症及相关病理，包括炎症和自身免疫疾病，如支气管哮喘、类风湿性关节炎、I型糖尿病、多发性硬化症、异体移植排斥、银屑病、炎症性肠病、溃疡性结肠炎、痤疮、动脉粥样硬化、癌症、瘙痒和过敏性鼻炎。还提供了含有本发明披露的化合物的药物组合物，以及使用这些化合物治疗支气管哮喘、慢性阻塞性肺病、类风湿性关节炎、多发性硬化症、I型糖尿病、银屑病、异体移植排斥、炎症性肠病、溃疡性结肠炎、痤疮、动脉粥样硬化、癌症、瘙痒、过敏性鼻炎以及其他炎症性和/或自身免疫障碍的方法。
• HETEROARYL CONTAINING BILE ACID ANALOGS AS FXR/TGR5 AGONISTS AND METHODS OF USE THEREOF
  申请人：ENANTA PHARMACEUTICALS, INC.

  公开号：US20170240587A1

  公开（公告）日：2017-08-24

  The present invention provides compounds of Formula I, pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated by FXR and/or TGR5.

  本发明提供了化合物I的化合物，包括这些化合物的药物组合物以及使用这些化合物来治疗或预防由FXR和/或TGR5介导的疾病或紊乱的方法。
• A facile synthesis of sulfonylureas via water assisted preparation of carbamates
  作者：Dinesh Kumar Tanwar、Anjali Ratan、Manjinder Singh Gill

  DOI：10.1039/c7ob00872d

  日期：——

  A novel and simple approach to the synthesis of sulfonylureas has been reported. It involved the reaction of various amines with diphenyl carbonate to yield the corresponding carbamates, which subsequently reacted with different sulphonamides to produce different sulfonylureas in excellent yields. The first reaction of diphenyl carbonate with amines was carried out in aqueous:organic (H2O:THF, 90:10)

  已经报道了一种新颖且简单的合成磺酰脲类的方法。它涉及各种胺与碳酸二苯酯的反应，以产生相应的氨基甲酸酯，其随后与不同的磺酰胺反应，以优异的产率产生不同的磺酰脲类。碳酸二苯酯与胺的第一反应是在室温下于水性：有机（H 2 O ：THF，90 : 10）介质中进行的，以生成氨基甲酸酯，该氨基甲酸酯与磺酰胺反应后，直接通向磺酰脲类。上述方法避免了传统的多步骤方案，并且避免使用有害，刺激性，有毒和对水分敏感的试剂，例如光气，异氰酸酯和/或氯甲酸酯。
• Substituted pyrazoles as p38 kinase inhibitors
  申请人：Naraian S. Ashok

  公开号：US20070078146A1

  公开（公告）日：2007-04-05

  A class of pyrazole derivatives is described for use in treating p38 kinase medicated disorders. Compounds of particular interest are defined by Formula IA wherein R 1 , R 2 , R 3 and R 4 are as described in the specification.

  描述了一类吡唑衍生物，用于治疗p38激酶介导的疾病。特别感兴趣的化合物由公式IA定义，其中R1、R2、R3和R4如规范中所述。
• Dihydroxypyrimidine carboxamide inhibitors of HIV integrase
  申请人：Di Francesco E. Maria

  公开号：US20070083045A1

  公开（公告）日：2007-04-12

  4,5-Dihydroxypyrimidine-6-carboxamides of formula: are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein R 1 , R 2 , R 3 and R 4 are defined herein. These compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

  本文描述了式子中R1，R2，R3和R4被定义的4,5-二羟基嘧啶-6-羧酰胺化合物，其作为HIV整合酶抑制剂和HIV复制抑制剂。这些化合物对于预防和治疗HIV感染以及预防、延迟AIDS发病和治疗AIDS非常有用。这些化合物可以作为化合物本身或药物可接受的盐形式用于对抗HIV感染和AIDS。这些化合物及其盐可以与其他抗病毒药物、免疫调节剂、抗生素或疫苗组合使用，作为制药组合物的成分。本文还描述了预防、治疗或延迟AIDS发病以及预防或治疗HIV感染的方法。