(E)-benzyl-(4-fluorobenzyl)-(3-p-tolylallyl)amine | 1152652-44-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-benzyl-(4-fluorobenzyl)-(3-p-tolylallyl)amine
• 英文别名: (E)-N-benzyl-N-[(4-fluorophenyl)methyl]-3-(4-methylphenyl)prop-2-en-1-amine
• CAS: 1152652-44-2
• 化学式: C₂₄H₂₄FN
• 分子量: 345.46
• InChiKey: BVCUPGWTEQLEOB-VMPITWQZSA-N

物化性质

• 沸点：
  464.2±33.0 °C(predicted)
• 密度：
  1.105±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苄基-(4-氟苄基)胺 、 1-(p-tolyl)allyl acetate 在 四丁基溴化铵 、 potassium carbonate 、 palladium dichloride 作用下， 以 甲苯 为溶剂， 反应 16.0h， 以78%的产率得到(E)-benzyl-(4-fluorobenzyl)-(3-p-tolylallyl)amine
  参考文献：
  名称：

  Palladium Nanoparticle-Catalyzed C−N Bond Formation. A Highly Regio- and Stereoselective Allylic Amination by Allyl Acetates

  摘要：

  Palladium nanoparticles, generated in situ from the reaction of palladium(II) chloride, have been demonstrated to be an efficient catalyst for C-N bond formation. A variety of aliphatic and aromatic amines have been allylated by substituted and unsubstituted allyl acetates in high yields by using palladium nanoparticles in the presence of a base without any ligand. The allylations are highly regio- and stereoselective.

  DOI：

  10.1021/jo9003037

文献信息

• Palladium Nanoparticle-Catalyzed C−N Bond Formation. A Highly Regio- and Stereoselective Allylic Amination by Allyl Acetates
  作者：Laksmikanta Adak、Kalicharan Chattopadhyay、Brindaban C. Ranu

  DOI：10.1021/jo9003037

  日期：2009.5.15

  Palladium nanoparticles, generated in situ from the reaction of palladium(II) chloride, have been demonstrated to be an efficient catalyst for C-N bond formation. A variety of aliphatic and aromatic amines have been allylated by substituted and unsubstituted allyl acetates in high yields by using palladium nanoparticles in the presence of a base without any ligand. The allylations are highly regio- and stereoselective.