N-(2-pyridyl)-p-toluenesulphinamide | 132145-90-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-pyridyl)-p-toluenesulphinamide
• 英文别名: 4-methyl-N-pyridin-2-ylbenzenesulfinamide
• CAS: 132145-90-5
• 化学式: C₁₂H₁₂N₂OS
• 分子量: 232.306
• InChiKey: SZYHHWYNWXSNKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  61.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  甲醇 、 N-(2-pyridyl)-p-toluenesulphinamide 在 bis(acetoxy)iodylbenzene 、 magnesium oxide 作用下， 以28%的产率得到Methoxy-(4-methylphenyl)-oxo-pyridin-2-ylimino-lambda6-sulfane
  参考文献：
  名称：

  Improved Method for the Iodine(III)-Mediated Preparation of Aryl Sulfonimidates

  摘要：

  One-pot hypervalent iodine-mediated oxidations of arylsulfinamides to arylsulfonimidates is reported. Contrary to the case of alkylsulfinamides, use of iodosobenzene was not satisfactory. The reaction worked best with diacetoxyiodosobenzene (DIB) and a mild base (MgO). The influence of substituents on the iodine(III) reagent arene has been examined.

  DOI：

  10.1021/ol052790t

文献信息

• Improved Method for the Iodine(III)-Mediated Preparation of Aryl Sulfonimidates
  作者：Anne Felim、Aurélie Toussaint、Courtney R. Phillips、Dominique Leca、Anna Vagstad、Louis Fensterbank、Emmanuel Lacôte、Max Malacria

  DOI：10.1021/ol052790t

  日期：2006.1.1

  One-pot hypervalent iodine-mediated oxidations of arylsulfinamides to arylsulfonimidates is reported. Contrary to the case of alkylsulfinamides, use of iodosobenzene was not satisfactory. The reaction worked best with diacetoxyiodosobenzene (DIB) and a mild base (MgO). The influence of substituents on the iodine(III) reagent arene has been examined.