6,7-二甲氧基-8-（3-甲基-2-丁烯-1-基）-2H-铬-2-酮 | 72916-61-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 6,7-二甲氧基-8-（3-甲基-2-丁烯-1-基）-2H-铬-2-酮
• 英文名称: O-methylcedrelopsin
• 英文别名: 2H-1-Benzopyran-2-one, 6,7-dimethoxy-8-(3-methyl-2-butenyl)-；6,7-dimethoxy-8-(3-methylbut-2-enyl)chromen-2-one
• CAS: 72916-61-1
• 化学式: C₁₆H₁₈O₄
• 分子量: 274.317
• InChiKey: NNBURDJZOIAAHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-hydroxy-7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one 、 重氮甲烷 生成 6,7-二甲氧基-8-（3-甲基-2-丁烯-1-基）-2H-铬-2-酮
  参考文献：
  名称：

  KOUL S. K.; DHAR K. L.; THAKUR R. S., INDIAN J. CHEM., 1979, B 17, NO 4, 396-397

  摘要：

  DOI：

文献信息

• Prenylcoumarins in One or Two Steps by a Microwave-Promoted Tandem Claisen Rearrangement/Wittig Olefination/Cyclization Sequence
  作者：Christiane Schultze、Bernd Schmidt

  DOI：10.1021/acs.joc.8b00667

  日期：2018.5.4

  overcome by a two-step synthesis consisting of a microwave-promoted tandem allyl ether Claisen rearrangement/Wittig olefination and a subsequent olefin cross metathesis with 2-methyl-2-butene. The cross metathesis step proceeds with a high selectivity and yields exclusively the desired prenyl, rather than the alternative crotyl substituent. Several naturally occurring 8-prenylcoumarins that were previously

  发现在微波条件下由1，1-二甲基烯丙基化的水杨醛和稳定的内酯[（乙氧基羰基）亚甲基]三苯基磷烷一锅法合成8-戊烯香豆素的范围有限。该序列遭受前体的困难且有时低收率的合成的困扰，并且遭受微波辐射下竞争性的脱丙烯基作用。这种副反应特别是在富电子的芳烃中发生，该芳烃的芳烃在相邻位置具有两个或多个烷氧基，这是天然存在的8-异戊二烯香豆素的显着取代方式。一步合成法的两个局限性都可以通过两步合成法克服，该合成法是由微波促进的串联烯丙基醚克莱森重排/维蒂希烯化反应和随后的烯烃与2-甲基-2-丁烯的交叉复分解反应组成的。交叉复分解步骤以高选择性进行，并且仅产生所需的异戊二烯基，而不是替代的巴豆基取代基。沿这条路线已经以良好的总收率合成了几种以前无法获得的天然存在的8-异戊二烯香豆素。
• PLANT-BASED INHIBITORS OF KETOHEXOKINASE FOR THE SUPPORT OF WEIGHT MANAGEMENT
  申请人：Rana Jatinder

  公开号：US20140377386A1

  公开（公告）日：2014-12-25

  A composition for inhibiting ketohexokinase, for example, ketohexokinase-C (KHK-C) activity, may include a plant extract exhibiting at least IC50 (i.e., 50% KHK-C inhibition at a concentration in the range of from about 0.1 μg/mL to about 1000 μg/mL. The composition may be in a form suitable for oral ingestion. A method for inhibiting KHK-C activity in a subject may include administering a plant extract that exhibits at least 50% KHK-C inhibition at a concentration from about 0.1 μg/mL to about 1000 μg/mL. The administering may be done to treat or prevent at least one of sugar addiction, obesity, or metabolic syndrome. The administering may be done to provide a diminished craving in the subject from at least one member selected from the group consisting of craving of sugar, fructose, fructose-containing sugars, carbohydrates, and combinations thereof. The subject may be pre-diabetic, diabetic and or insulin resistant.
• KOUL S. K.; DHAR K. L.; THAKUR R. S., INDIAN J. CHEM., 1979, B 17, NO 4, 396-397
  作者：KOUL S. K.、 DHAR K. L.、 THAKUR R. S.

  DOI：——

  日期：——