N,N'-bis-pivaloyl-2-methyl-2-thiopseudourea | 318972-68-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 异硫脲类
• 英文名称: N,N'-bis-pivaloyl-2-methyl-2-thiopseudourea
• 英文别名: methyl N,N'-bis(2,2-dimethylpropanoyl)carbamimidothioate
• CAS: 318972-68-8
• 化学式: C₁₂H₂₂N₂O₂S
• 分子量: 258.385
• InChiKey: PZIZEYIIXAAIIJ-UHFFFAOYSA-N

物化性质

• 密度：
  1.03±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  83.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-Methyl-2-thiopseudourea.1/2H2SO4 、 三甲基乙酰氯 、 碳酸氢钠 生成 N,N'-bis-pivaloyl-2-methyl-2-thiopseudourea
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Guanidinium functionalized oligomers and methods
  申请人：——

  公开号：US20030092046A1

  公开（公告）日：2003-05-15

  The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligomers are useful for diagnostic, therapeutic and investigative purposes.

  本发明提供了寡核苷酸，它们与RNA或DNA的选定序列具有特异性杂交性，其中至少一个核苷酸基团被修饰以包括一种鸟氨酸基团。这些寡核苷酸对于诊断、治疗和调查目的非常有用。
• hTERT modulators and methods of use
  申请人：Arizona Board of Regents on Behalf of the University of Arizona

  公开号：US10556860B2

  公开（公告）日：2020-02-11

  The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula as described herein. Some aspects of the invention are based on the characterization of the effect of hTERT core promoter region mutants on the 5-12 G-quadruplex structure and its stability. It is believed that some of the compounds of the invention bind selectively to the G-quadruplex in the hTERT core promoter mutant, which results in reversal of the effect of mutant promoter activation.

  本发明提供了 hTERT 调节剂及其生产和使用方法。特别是，本发明提供了如本文所述的式化合物。本发明的某些方面基于 hTERT 核心启动子区突变体对 5-12 G-四链结构及其稳定性影响的表征。据信，本发明的某些化合物可选择性地与 hTERT 核心启动子突变体中的 G-四叉体结合，从而逆转突变体启动子激活的效应。
• GUANIDINIUM FUNCTIONALIZED OLIGOMERS AND METHODS
  申请人：ISIS PHARMACEUTICALS, INC.

  公开号：EP1206574A2

  公开（公告）日：2002-05-22
• EP1206574A4
  申请人：——

  公开号：EP1206574A4

  公开（公告）日：2002-10-16
• hTERT MODULATORS AND METHODS OF USE
  申请人：THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARZONA

  公开号：US20180346415A1

  公开（公告）日：2018-12-06

  The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula as described herein. Some aspects of the invention are based on the characterization of the effect of hTERT core promoter region mutants on the 5-12 G-quadruplex structure and its stability. It is believed that some of the compounds of the invention bind selectively to the G-quadruplex in the hTERT core promoter mutant, which results in reversal of the effect of mutant promoter activation.