2β-Brom-3α-p-toluolsulfonyloxy-cholestan | 1667-86-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 2β-Brom-3α-p-toluolsulfonyloxy-cholestan
• 英文别名: 2β-bromo-3α-(toluene-4-sulfonyloxy)-5α-cholestane；2β-Brom-3α-(toluol-4-sulfonyloxy)-5α-cholestan；[(2S,3S,5S,8R,9S,10S,13R,14S,17R)-2-bromo-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] 4-methylbenzenesulfonate
• CAS: 1667-86-3
• 化学式: C₃₄H₅₃BrO₃S
• 分子量: 621.763
• InChiKey: KDTMFOXQNIRBEI-UAZZBPAMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.9
• 重原子数：
  39
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2β-Brom-3α-p-toluolsulfonyloxy-cholestan 在 三甘醇二甲醚 作用下， 生成 3β-Brom-2α-p-toluolsulfonyloxy-cholestan
  参考文献：
  名称：

  反应机理研究：I. 溴醇磺酸酯的双轴→双轴重排

  摘要：

  3α-溴胆甾醇-2β-基对甲苯磺酸盐在溶液中加热时重新排列成平衡混合物，其中二赤道异构体，2α-溴胆甾醇-3β-基对甲苯磺酸盐占主导地位。...

  DOI：

  10.1139/v63-319
• 作为产物：
  描述：

  2β-bromo-3α-hydroxy-5-α-cholestane 、 对甲苯磺酰氯 生成 2β-Brom-3α-p-toluolsulfonyloxy-cholestan
  参考文献：
  名称：

  Asymmetry between encoding and retrieval processes: Evidence from divided attention and a calibration analysis

  摘要：

  Two experiments provide further information on the effects of divided attention (DA) on encoding and retrieval processes. The first experiment examined the effects of decision and motor difficulty of a concurrent reaction time task. A calibration analysis was used in the second experiment to test the hypothesis that shifting attentional emphasis away from encoding to the secondary task reduces the level of processing the to-be-remembered items receive. Overall, the results confirm and extend the conclusions of Craik, Govoni, Naveh-Benjamin, and Anderson (1996) and Naveh-Benjamin, Craik, Guez, and Dori (1998), by pointing to clear differences between encoding and retrieval processes: Encoding is affected by simultaneous task demands, especially those associated with "central" resources involved in conscious decision making, whereas retrieval is obligatory in that it is largely immune to the effects of simultaneous demands. The results of the calibration analysis suggest that one reason for the poorer memory performance as a result of DA at encoding is a qualitative shift to less deep, elaborative strategies.

  DOI：

  10.3758/bf03209344

文献信息

• Asymmetry between encoding and retrieval processes: Evidence from divided attention and a calibration analysis
  作者：Moshe Naveh-Benjamin、Fergus I. M. Craik、Dana Gavrilescu、Nicole D. Anderson

  DOI：10.3758/bf03209344

  日期：2000.11

  Two experiments provide further information on the effects of divided attention (DA) on encoding and retrieval processes. The first experiment examined the effects of decision and motor difficulty of a concurrent reaction time task. A calibration analysis was used in the second experiment to test the hypothesis that shifting attentional emphasis away from encoding to the secondary task reduces the level of processing the to-be-remembered items receive. Overall, the results confirm and extend the conclusions of Craik, Govoni, Naveh-Benjamin, and Anderson (1996) and Naveh-Benjamin, Craik, Guez, and Dori (1998), by pointing to clear differences between encoding and retrieval processes: Encoding is affected by simultaneous task demands, especially those associated with "central" resources involved in conscious decision making, whereas retrieval is obligatory in that it is largely immune to the effects of simultaneous demands. The results of the calibration analysis suggest that one reason for the poorer memory performance as a result of DA at encoding is a qualitative shift to less deep, elaborative strategies.
• REACTION MECHANISM STUDIES: I. THE DIAXIAL → DIEQUATORIAL REARRANGEMENT OF BROMOHYDRIN SULPHONATE ESTERS
  作者：J. F. King、R. G. Pews、R. A. Simmons

  DOI：10.1139/v63-319

  日期：1963.9.1

  3α-Bromocholestan-2β-yl p-toluenesulphonate on heating in solution rearranges to an equilibrium mixture in which the diequatorial isomer, 2α-bromocholestan-3β-yl p-toluenesulphonate, predominates. ...

  3α-溴胆甾醇-2β-基对甲苯磺酸盐在溶液中加热时重新排列成平衡混合物，其中二赤道异构体，2α-溴胆甾醇-3β-基对甲苯磺酸盐占主导地位。...