4-chloro-2-[(6-piperazin-1-ylsulfonyl-1H-benzimidazol-2-yl)amino]phenol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 4-chloro-2-[(6-piperazin-1-ylsulfonyl-1H-benzimidazol-2-yl)amino]phenol
• 化学式: C₁₇H₁₈ClN₅O₃S
• 分子量: 407.9
• InChiKey: GZYNFEOLSVFYOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  119
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• SUBSTITUTED- 1H-BENZO[D]IMIDAZOLE SERIES COMPOUNDS AS LYSINE-SPECIFIC DEMETHYLASE 1 (LSD1) INHIBITORS
  申请人：University of Utah

  公开号：US20150065495A1

  公开（公告）日：2015-03-05

  The present invention provides compounds which are useful as inhibitors of lysine-specific demethylase 1 (“LSD1”). The present invention also relates to pharmaceutical compositions containing these compounds. The present invention also relates to a method for preparing these compounds. The present invention also relates to a method of treating a mammalian disorder in which LSD1 levels are elevated by administering these compounds and compositions to a patient in need thereof. The present invention also relates to a method for decreasing histone demethylase activity in a mammal comprising administering to the mammal an effective amount of these compounds and compositions.

  本发明提供了一些化合物，这些化合物可用作赖氨酸特异性去甲基化酶1（“LSD1”）的抑制剂。本发明还涉及含有这些化合物的制药组合物。本发明还涉及制备这些化合物的方法。本发明还涉及通过向需要治疗的患者给予这些化合物和组合物来治疗LSD1水平升高的哺乳动物疾病的方法。本发明还涉及一种降低哺乳动物组织中组蛋白去甲基化酶活性的方法，包括向哺乳动物中施用这些化合物和组合物的有效量。
• US9556170B2
  申请人：——

  公开号：US9556170B2

  公开（公告）日：2017-01-31
• [EN] SUBSTITUTED-1H-BENZO[D]IMIDAZOLE SERIES COMPOUNDS AS LYSINE-SPECFIC DEMETHYLASE 1 (LSD1) INHIBITORS<br/>[FR] COMPOSÉS DE LA SÉRIE DES 1H-BENZO[D]IMIDAZOLES SUBSTITUÉS À TITRE D'INHIBITEURS DE DÉMÉTHYLASE 1 SPÉCIFIQUE DE LA LYSINE (LSD1)
  申请人：UNIV UTAH

  公开号：WO2015031564A2

  公开（公告）日：2015-03-05

  The present invention provides compounds which are useful as inhibitors of lysine-specific demethylase 1 ("LSD1"). The present invention also relates to pharmaceutical compositions containing these compounds. The present invention also relates to a method for preparing these compounds. The present invention also relates to a method of treating a mammalian disorder in which LSD1 levels are elevated by administering these compounds and compositions to a patient in need thereof. The present invention also relates to a method for decreasing histone demethylase activity in a mammal comprising administering to the mamal an effective amount of these compounds and compositions.