4,5,6-Triethylpyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4,5,6-Triethylpyrimidine
• 英文别名: 4,5,6-triethylpyrimidine
• 化学式: C₁₀H₁₆N₂
• 分子量: 164.25
• InChiKey: AKFKNONWZQBTTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
  申请人：AMGEN INC.

  公开号：US20180177767A1

  公开（公告）日：2018-06-28

  Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

  本文提供了KRAS G12C抑制剂，其组成，以及使用方法。这些抑制剂对治疗多种疾病有用，包括胰腺癌、结直肠癌和肺癌。
• Organic molecules for use in organic devices
  申请人：CYNORA GMBH

  公开号：US11276825B2

  公开（公告）日：2022-03-15

  An organic molecules for use in optoelectronic devices is disclosed having a structure of formula A1: where A, RN, Ra and R2 are as defined herein.

  公开了一种用于光电子器件的有机分子，其结构式为A1:其中A，RN，Ra和R2的定义如本文所述。
• BENZOISOTHIAZOLE, ISOTHIAZOLO[3,4-B]PYRIDINE, QUINAZOLINE, PHTHALAZINE, PYRIDO[2,3-D]PYRIDAZINE AND PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS FOR TREATING LUNG, PANCREATIC OR COLORECTAL CANCER
  申请人：Amgen Inc.

  公开号：EP4001269A1

  公开（公告）日：2022-05-25

  Provided herein are compounds of formulae (I), (II), (III), (III´), (IV), (IV´) and (V): as KRAS G12C inhibitors for use in treating cancer, such as e.g. pancreatic, colorectal and lung cancer. Preferred compounds are e.g. benzoisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives. An exemplary compound is e.g. 1-(4-(6-(2-bromo-5-hydroxyphenyl)-5-chloro-7-fluorobenzo[c]isothiazol-3-yl)piperazin-1-yl)prop-2-en-1-one (example 1-1):

  这里提供的是式 (I)、(II)、(III)、(III´)、(IV)、(IV´) 和 (V) 的化合物： 作为 KRAS G12C 抑制剂用于治疗癌症，如胰腺癌、结直肠癌和肺癌。 首选化合物为苯并异噻唑、异噻唑并[3,4-b]吡啶、喹唑啉、酞嗪、吡啶并[2,3-d]哒嗪和吡啶并[2,3-d]嘧啶衍生物等。 例如，1-(4-(6-(2-溴-5-羟基苯基)-5-氯-7-氟苯并[c]异噻唑-3-基)哌嗪-1-基)丙-2-烯-1-酮（例 1-1）就是一种示例性化合物：
• PHTHALIMID UND CARBAZOL ODER DESSEN ANALOGE ENTHALTENDE VERBINDUNGEN ZUR VERWENDUNG IN ORGANISCHEN OPTOELEKTRONISCHEN VORRICHTUNGEN
  申请人：CYNORA GMBH

  公开号：EP3279193B1

  公开（公告）日：2019-05-08
• ORGANIC MOLECULES FOR USE IN ORGANIC DEVICES
  申请人：CYNORA GMBH

  公开号：US20210184134A1

  公开（公告）日：2021-06-17

  The invention relates to purely organic molecules of formula A1 and to the use thereof in optoelectronic devices where A is the same or different at each instance and is CR b or N; R N is methyl, phenyl, xylyl, mesityl, naphthyl, biphenyl, naphthylphenyl, terphenyl or 2,4,6-triphenylphenyl; R a is the same or different at each instance and is H, deuterium, an alkyl group or an aryl group; R 1 at each instance is an aryl group which is unsubstituted or substituted by one or more R 2 ; R 2 is the same or different at each instance and is F, CF 3 or CN; where at least one and at most four A are N or at least one R b is selected from the group consisting of CF 3 , C(═O)R 1 , CN, an alkyl group substituted by one or more R 2 , aryl group substituted by one or more R 2 and/or by one or more unsubstituted alkyl groups and/or by one or more unsubstituted or alkyl-substituted aryl groups, a heteroaryl group which is unsubstituted or substituted by one or more R 2 and/or by one or more unsubstituted alkyl groups and/or by one or more unsubstituted or alkyl-substituted aryl groups and a group of the sub-formula T1 or T2: where A, R N , R a and R 2 are as defined herein.