1,3-bis((3-(4-vinylbenzyloxy)pyridin-2-yl)methylamino)propan-2-ol | 1331826-38-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-bis((3-(4-vinylbenzyloxy)pyridin-2-yl)methylamino)propan-2-ol
• 英文别名: VB(bpdpo)；1,3-Bis[[3-[(4-ethenylphenyl)methoxy]pyridin-2-yl]methylamino]propan-2-ol；1,3-bis[[3-[(4-ethenylphenyl)methoxy]pyridin-2-yl]methylamino]propan-2-ol
• CAS: 1331826-38-0
• 化学式: C₃₃H₃₆N₄O₃
• 分子量: 536.674
• InChiKey: ZXVIXLSTPGLMAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  40
• 可旋转键数：
  16
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  88.5
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  二氯甲烷 、 1,3-bis((3-(4-vinylbenzyloxy)pyridin-2-yl)methylamino)propan-2-ol 、 sodium perchlorate 、 copper(II) acetate monohydrate 以 乙醇 为溶剂， 以24%的产率得到N,N'-[bis(3-(4-vinylbenzyloxy)-2-pyridylmethyl)-1,3-diaminopropan-2-ol]ato(μ-acetato) dicopper(II) diperchlorate*dichloromethane
  参考文献：
  名称：

  Hydrolysis of Glycosides with Microgel Catalysts

  摘要：

  A dormant macromolecular catalyst was prepared by polymerization of an aqueous styrene-butyl acrylate miniemulsion in the presence of a new polymerizable pentadentate ligand. The catalyst was activated by binding Cu(II) ions to the ligand site and then explored for its ability to hydrolyze glycosidic bonds in alkaline solution. The performance was correlated to the catalytic activity shown by low molecular weight analogs. A turnover rate of up to 43 x 10(-4) min(-1) was previously observed for cleavage of the glycosidic bond in selected p-nitrophenylglycosides with a binuclear, low molecular weight catalyst; by contrast, the same reaction is more than 1 order of magnitude faster and has a turnover rate of up to 380 x 10(-4) min(-1) when using the prepared macromolecular catalyst. The catalyzed hydrolysis is about 10(5)-fold accelerated over the uncatalyzed background reaction under the provided conditions, while a significant discrimination of the alpha- and beta-glycosidic bond or of the galacto- and gluco-configuration in the sugar moiety in the glycoside substrates is not observed.

  DOI：

  10.1021/ic200837z
• 作为产物：
  描述：

  3-羟基-2-羟甲基吡啶盐酸盐 在 selenium(IV) oxide 、 sodium tetrahydroborate 、 potassium iodide 、 potassium hydroxide 作用下， 以 1,4-二氧六环 、 甲醇 、 水 为溶剂， 反应 87.0h， 生成 1,3-bis((3-(4-vinylbenzyloxy)pyridin-2-yl)methylamino)propan-2-ol
  参考文献：
  名称：

  Hydrolysis of Glycosides with Microgel Catalysts

  摘要：

  A dormant macromolecular catalyst was prepared by polymerization of an aqueous styrene-butyl acrylate miniemulsion in the presence of a new polymerizable pentadentate ligand. The catalyst was activated by binding Cu(II) ions to the ligand site and then explored for its ability to hydrolyze glycosidic bonds in alkaline solution. The performance was correlated to the catalytic activity shown by low molecular weight analogs. A turnover rate of up to 43 x 10(-4) min(-1) was previously observed for cleavage of the glycosidic bond in selected p-nitrophenylglycosides with a binuclear, low molecular weight catalyst; by contrast, the same reaction is more than 1 order of magnitude faster and has a turnover rate of up to 380 x 10(-4) min(-1) when using the prepared macromolecular catalyst. The catalyzed hydrolysis is about 10(5)-fold accelerated over the uncatalyzed background reaction under the provided conditions, while a significant discrimination of the alpha- and beta-glycosidic bond or of the galacto- and gluco-configuration in the sugar moiety in the glycoside substrates is not observed.

  DOI：

  10.1021/ic200837z

文献信息

• TEMPLATED ANTIMICROBIAL MICROGELS AND METHODS OF MAKING AND USING THE SAME
  申请人：THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

  公开号：US20220125056A1

  公开（公告）日：2022-04-28

  Disclosed herein are antimicrobial materials comprising a carbohydrate-templated microgel and a plurality of metal ions complexed thereto. The carbohydrate-templated microgel comprises a network copolymer molecule comprising a monoacrylate monomer, a crosslinking monomer, and a ligand monomer and wherein the microgel is prepared by the copolymerization of the monoacrylate monomer, the crosslinking monomer, and the ligand monomer in the presence of a carbohydrate or a carbohydrate derivative. The microgels have antimicrobial activity and allow for implementation of multiple, simultaneous mechanisms of antimicrobial action.
• Hydrolysis of Glycosides with Microgel Catalysts
  作者：Susanne Striegler、Michael Dittel、Rami Kanso、Natasha A. Alonso、Evert C. Duin

  DOI：10.1021/ic200837z

  日期：2011.9.19

  A dormant macromolecular catalyst was prepared by polymerization of an aqueous styrene-butyl acrylate miniemulsion in the presence of a new polymerizable pentadentate ligand. The catalyst was activated by binding Cu(II) ions to the ligand site and then explored for its ability to hydrolyze glycosidic bonds in alkaline solution. The performance was correlated to the catalytic activity shown by low molecular weight analogs. A turnover rate of up to 43 x 10(-4) min(-1) was previously observed for cleavage of the glycosidic bond in selected p-nitrophenylglycosides with a binuclear, low molecular weight catalyst; by contrast, the same reaction is more than 1 order of magnitude faster and has a turnover rate of up to 380 x 10(-4) min(-1) when using the prepared macromolecular catalyst. The catalyzed hydrolysis is about 10(5)-fold accelerated over the uncatalyzed background reaction under the provided conditions, while a significant discrimination of the alpha- and beta-glycosidic bond or of the galacto- and gluco-configuration in the sugar moiety in the glycoside substrates is not observed.