1-(bis(2-azidoethoxy)methyl)-4-methoxybenzene | 1236970-07-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(bis(2-azidoethoxy)methyl)-4-methoxybenzene
• 英文别名: 1-[Bis(2-azidoethoxy)methyl]-4-methoxybenzene；1-[bis(2-azidoethoxy)methyl]-4-methoxybenzene
• CAS: 1236970-07-2
• 化学式: C₁₂H₁₆N₆O₃
• 分子量: 292.297
• InChiKey: RCSCOAHPYFDBOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  56.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1-(bis(2-chloroethoxy)methyl)-4-methoxybenzene 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 10.0h， 以31%的产率得到1-(bis(2-azidoethoxy)methyl)-4-methoxybenzene
  参考文献：
  名称：

  Nanoparticles and nanoparticle compositions

  摘要：

  本发明提供了多价表面交联微胶粒（SCM）颗粒、交联反向微胶粒（CRM）颗粒，以及它们的制造和使用方法。例如，SCM颗粒可用于阻止病毒或细菌与宿主细胞结合。这种阻止作用可用于治疗流感、癌症或艾滋病。而CRM颗粒可用于制备金属或金属合金纳米颗粒，或用于催化反应。

  公开号：

  US09320713B2

文献信息

• NANOPARTICLES AND NANOPARTICLE COMPOSITIONS
  申请人：Zhao Yan

  公开号：US20130101516A1

  公开（公告）日：2013-04-25

  The invention provides multivalent surface-crosslinked micelle (SCM) particles, crosslinked reverse micelle (CRM) particles, and methods of making and using them. The SCM particles can be used, for example, to inhibit a virus or bacteria from binding to a host cell. The inhibition can be used in therapy for the flu, cancer, or AIDS. The CRM particles can be used, for example, to prepare metal nanoparticles or metal alloy nanoparticles, or they can be used in catalytic reactions.

  本发明提供了多价表面交联微胶粒（SCM）颗粒、交联反向微胶粒（CRM）颗粒，以及它们的制造和使用方法。例如，SCM颗粒可用于阻止病毒或细菌与宿主细胞结合。这种抑制作用可用于治疗流感、癌症或艾滋病。CRM颗粒可用于制备金属纳米颗粒或金属合金纳米颗粒，或用于催化反应。
• Rapid Release of Entrapped Contents from Multi-Functionalizable, Surface Cross-Linked Micelles upon Different Stimulation
  作者：Shiyong Zhang、Yan Zhao

  DOI：10.1021/ja103391k

  日期：2010.8.11

  Hydrophobic guests such as pyrene could be readily trapped inside the micelles of an alkynylated surfactant in the presence of an azide-functionalized cross-linker using the click reaction. The cross-linker was designed to contain cleavable bonds such as geminal diol, disulfide, and acetal. The resulting pyrene-containing water-soluble nanoparticle was under electrostatic stress when diluted below the CMC of the surfactant. Extremely rapid (<1 min) release of the hydrophobic content was observed when the cross-linker was cleaved. This method combines the ease of physical entrapment and the precision of chemical ligation, and potentially is highly useful in the delivery and controlled release of pharmaceutical agents.
• US8790621B2
  申请人：——

  公开号：US8790621B2

  公开（公告）日：2014-07-29
• US9320713B2
  申请人：——

  公开号：US9320713B2

  公开（公告）日：2016-04-26
• [EN] NANOPARTICLES AND NANOPARTICLE COMPOSITIONS<br/>[FR] NANOPARTICULES ET COMPOSITIONS DE NANOPARTICULES
  申请人：UNIV IOWA STATE RES FOUND INC

  公开号：WO2011130114A1

  公开（公告）日：2011-10-20

  The invention provides multivalent surface-crosslinked micelle (SCM) particles, crosslinked reverse micelle (CRM) particles, and methods of making and using them. The SCM particles can be used, for example, to inhibit a virus or bacteria from binding to a host cell. The inhibition can be used in therapy for the flu, cancer, or AIDS. The CRM particles can be used, for example, to prepare metal nanoparticles or metal alloy nanoparticles, or they can be used in catalytic reactions.