2,4,5-Trifluororesorcinol | 35770-72-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2,4,5-Trifluororesorcinol
• 英文别名: 2,4,5-Trifluorobenzene-1,3-diol
• CAS: 35770-72-0
• 化学式: C₆H₃F₃O₂
• 分子量: 164.084
• InChiKey: ULPUUNVDJJXSRH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,4,5-Trifluororesorcinol 在 dimethyl sulfide borane 、 硫酸 、 三苯基膦 、 lithium hydroxide 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 、 甲苯 为溶剂， 反应 36.08h， 生成 7-(benzyloxy)-5,6,8-trifluoro-4-(2-hydroxyethyl)-2H-chromen-2-one
  参考文献：
  名称：

  氟香豆素赖氨酸衍生物的合成及光谱性质

  摘要：

  荧光氨基酸向蛋白质中的位点选择性掺入已经成为可表达的蛋白质报道分子的有价值的替代物。为了成功应用，需要一种稳健，可扩展但灵活的途径来合成非天然氨基酸。这项工作描述了香豆素共轭赖氨酸衍生物的改进的合成方法，其中有氟化的变体。这些类似物可在低pH值下使用，应用于探测在酸性条件下运行的生物过程。

  DOI：

  10.1021/acs.joc.7b03214
• 作为产物：
  描述：

  五氟硝基苯 在 palladium on activated charcoal 盐酸 、 氢气 、 亚膦酸 、 三溴化硼 、 sodium nitrite 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 、 乙酸乙酯 为溶剂， 4.0~20.0 ℃ 、275.79 kPa 条件下， 反应 2.25h， 生成 2,4,5-Trifluororesorcinol
  参考文献：
  名称：

  Synthesis of Fluorinated Fluoresceins

  摘要：

  Several novel fluorinated fluoresceins (Oregon Green dyes) were prepared by the reaction of fluororesorcinols with phthalic anhydride and its derivatives. A novel regiospecific synthesis of fluororesorcinols was key to the successful synthesis of these new fluorophores. (Polyfluoro)-nitrobenzenes were reacted with 2 equiv of sodium methoxide followed by reduction, hydrodediazoniation, and demethylation, giving the first straightforward synthesis of 2-fluororesorcinol, 4-fluororesorcinol, 2,4-difluororesorcinol, and 2,4,5-trifluororesorcinol. These fluorinated fluoresceins have higher photostability and ionize at a lower pH (pK(a) = 3.3-6.1) than fluorescein (pK(a) = 6.5). Some of the fluorinated fluoresceins have very high quantum yields (0.85-0.97), which, in combination with their lower pK(a)s and high photostability, makes them superior fluorescent dyes for use as reporter molecules in biological systems.

  DOI：

  10.1021/jo9706178

文献信息

• Fluorinated resorufin compounds and their application
  申请人：Batchelor Robert

  公开号：US20050096315A1

  公开（公告）日：2005-05-05

  The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.

  这项发明提供了新颖的氟化resorufin化合物，可用于各种测定格式。还提供了使用这些化合物的方法，以及包括该发明化合物和详细说明如何在一个或多个测定格式中使用该化合物的试剂盒。
• Process for the preparation of halogenated (meth)acrylic esters and poly (meth) arcylates obtained with said (meth)acrylic esters
  申请人：Akzo Nobel N.V.

  公开号：EP0824096A2

  公开（公告）日：1998-02-18

  The present invention is directed to a process for the preparation of (meth)acrylates of halogenated alcohols by direct esterification of said alcohols with (meth)acrylic acid (chloride) wherein at least 2,6-substituted pyridine derivative is used as a polymerization inhibitor at room temperature or lower. Suitable at least 2,6-substituted pyridine derivatives are 2,6-lutidine, 2,4,6-collidine or 2,6-di-tert.butyl-4-methyl pyridine. With the halogenated (meth)acrylate esters prepared with the process according to the invention, very pure homo- and copolymers can be prepared, resulting in polymers having a low optical loss of 0.1 dB/cm or lower at 1300 nm and lower than 0.4 dB/cm at 1550 nm.

  本发明涉及一种通过将卤代醇与（甲基）丙烯酸（氯化物）直接酯化来制备（甲基）丙烯酸酯的方法，其中至少使用一种2,6-取代吡啶衍生物作为聚合抑制剂，温度为室温或更低。适用的至少2,6-取代吡啶衍生物包括2,6-吡啶、2,4,6-考林或2,6-二叔丁基-4-甲基吡啶。 通过根据本发明的方法制备的卤代（甲基）丙烯酸酯，可以制备非常纯净的同聚物和共聚物，从而得到在1300纳米处光学损耗低至0.1 dB/cm或更低，在1550纳米处低于0.4 dB/cm的聚合物。
• Fluorinated xanthene derivatives
  申请人：Molecular Probes, Inc.

  公开号：EP1441010A1

  公开（公告）日：2004-07-28

  The family of dyes of the invention are fluoresceins and rhodols that are directly substituted on one or more aromatic carbons by fluorine. These fluorine-substituted fluorescent dyes possess greater photostability and have lower sensitivity to pH changes in the physiological range of 6-8 than do non-fluorinated dyes, exhibit less quenching when conjugated to a substance, and possess additional advantages. The dyes of the invention are useful as detectable tracers and for preparing conjugates of organic and inorganic substances.

  本发明的染料系列是在一个或多个芳香碳上直接被氟取代的荧光素和荧光铑。与非氟化染料相比，这些氟取代的荧光染料具有更高的光稳定性，在 6-8 生理范围内对 pH 值变化的敏感性较低，与物质共轭时淬灭程度较低，并具有其他优点。本发明的染料可用作可检测的示踪剂，也可用于制备有机和无机物质的共轭物。
• Fluorinated resorufin compounds and their application in detecting hydrogen peroxide
  申请人：Molecular Probes Inc.

  公开号：EP2298312A1

  公开（公告）日：2011-03-23

  The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.

  本发明提供了可用于多种检测形式的新型氟化树脂素化合物。此外，本发明还提供了使用这些化合物的方法，以及包含本发明化合物的试剂盒和在一种或多种检测方法中使用该化合物的详细说明。
• Ethylened polymer and molded object obtained therefrom
  申请人：Satoh Yasuo

  公开号：US20060135712A1

  公开（公告）日：2006-06-22

  An ethylene-based polymer which is an ethylene/C4 to C10 α-olefin copolymer and satisfies the following requirements [k1] to [k3]: [k1] melt flow rate (MFR) under a loading of 2.16 kg at 190° C. is in the range of 1.0 to 50 g/10 minutes; [k2] LNR defined as a scale of neck-in upon film molding is in the range of 0.6 to 1.4; and [k3] take-up speed at break [DS (m/min)] at 160° C. and melt flow rate (MFR) satisfy the following relationship (Eq-1): 12×MFR 0.577 ≦DS≦165×MFR 0.577 (Eq-1), and a thermoplastic resin composition containing the ethylene-based polymer, provide a molded product, preferably a film, excellent in moldability and mechanical strength. The ethylene-based polymer can be efficiently obtained by polymerization in the presence of an olefin polymerization catalyst formed from a solid carrier, (A) a solid transition metal catalyst component obtained by contacting (a) a compound of a transition metal of the group 4 in the periodic table, containing at least one ligand having a cyclopentadienyl skeleton, (b) an organoaluminum oxy compound, (c) a multifunctional organic halide, and if necessary (d) an organoaluminum compound, and if necessary (B) organoaluminum compound.

  一种乙烯基聚合物，它是一种乙烯/C4 至 C10 α-烯烃共聚物，并满足以下[k1]至[k3]的要求：[k1] 熔体流动速率（MFR）在 190 摄氏度、负载 2.16 千克的条件下，范围在 1.0 至 50 克/10 分钟之间；[k2] LNR 定义为薄膜成型时的缩颈比例，范围在 0.6 至 1.4 之间；以及 [k3] 160 摄氏度时的断裂收口速度[DS（米/分）]和熔体流动速率（MFR）满足以下关系式（公式-1）：12×MFR 0.577 ≦DS≦165×MFR 0.577 (式-1），以及含有乙烯基聚合物的热塑性树脂组合物，可提供模塑产品，最好是薄膜，具有优异的模塑性和机械强度。乙烯基聚合物可通过在由固体载体、(A)固体过渡金属催化剂组分、(B)有机铝氧化合物、(C)多功能有机卤化物和必要时(D)有机铝化合物以及必要时(B)有机铝化合物形成的烯烃聚合催化剂存在下进行聚合而有效地获得。