5-Propan-2-ylsulfonylpyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-Propan-2-ylsulfonylpyrimidine
• 英文别名: 5-propan-2-ylsulfonylpyrimidine
• 化学式: C₇H₁₀N₂O₂S
• 分子量: 186.23
• InChiKey: KWBYGRMJCQLTQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  68.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Methods and compositions for inhibition of Ras
  申请人：ARAXES PHARMA LLC

  公开号：US10011600B2

  公开（公告）日：2018-07-03

  Inhibitors of Ras protein, methods to modulate the activity of Ras protein, and methods of treatment of disorders mediated by Ras protein are provided. A method for regulating activity of a K-Ras, H-Ras or N-Ras mutant protein with a compound is described. Disorders that can be treated include cancer, such as hematological cancer, pancreatic cancer, MYH associated polyposis, colorectal cancer, or lung cancer.

  提供了 Ras 蛋白的抑制剂、调节 Ras 蛋白活性的方法以及治疗由 Ras 蛋白介导的疾病的方法。描述了一种用化合物调节 K-Ras、H-Ras 或 N-Ras 突变蛋白活性的方法。可治疗的疾病包括癌症，如血癌、胰腺癌、MYH 相关性息肉病、结直肠癌或肺癌。
• Substituted quinazoline compounds and methods of use
  申请人：ARAXES PHARMA LLC

  公开号：US10822312B2

  公开（公告）日：2020-11-03

  The present disclosure provides inhibitors of Ras protein of Formula (I-A): Also disclosed are methods to modulate the activity of Ras protein and methods of treatment of disorders mediated by Ras protein with compounds of Formula (I-A).

  本公开提供了式 (I-A) 的 Ras 蛋白抑制剂： 还公开了用式（I-A）化合物调节 Ras 蛋白活性的方法和治疗由 Ras 蛋白介导的疾病的方法。
• Filamin A binding compounds and their use as anti-inflammatory and analgesic agents
  申请人：Pain Therapeutics, Inc.

  公开号：EP2918587B1

  公开（公告）日：2018-04-04
• METHODS AND COMPOSITIONS FOR INHIBITION OF RAS
  申请人：ARAXES PHARMA LLC

  公开号：US20170247376A1

  公开（公告）日：2017-08-31

  Inhibitors of Ras protein, methods to modulate the activity of Ras protein, and methods of treatment of disorders mediated by Ras protein are provided. A method for regulating activity of a K-Ras, H-Ras or N-Ras mutant protein with a compound is described. Disorders that can be treated include cancer, such as hematological cancer, pancreatic cancer, MYH associated polyposis, colorectal cancer, or lung cancer.
• SUBSTITUTED QUINAZOLINE COMPOUNDS AND METHODS OF USE
  申请人：ARAXES PHARMA LLC

  公开号：US20190127336A1

  公开（公告）日：2019-05-02

  The present disclosure provides inhibitors of Ras protein. Also disclosed are methods to modulate the activity of Ras protein and methods of treatment of disorders mediated by Ras protein.