(2R,4R,5R)-5-[(2-azaniumylacetyl)amino]-2-[[(2R,3R,5R)-3,4-dihydroxy-5-(4-methyl-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: (2R,4R,5R)-5-[(2-azaniumylacetyl)amino]-2-[[(2R,3R,5R)-3,4-dihydroxy-5-(4-methyl-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
• 化学式: C21H33N4O16P
• 分子量: 628.5
• InChiKey: PNCOXDHQFHBYOH-QMAKXQNDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.4
• 重原子数：
  42
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  325
• 氢给体数：
  9
• 氢受体数：
  16

文献信息

• Nucleotide Sugar Purification Using Membranes
  申请人：Felo Michael

  公开号：US20090048440A1

  公开（公告）日：2009-02-19

  The invention provides methods of removing contaminants from a mixture of a desired product and contaminants by pH adjustments and molecular weight cut-offs. The contaminants include phosphate groups, magnesium sulfate, sodium pyruvate and tetrasodium pyrophosphate groups. The desired product includes nucleotide sugars, glycolipids, LnNT, sialyl lactose, and salts.
• PROCESS FOR THE PRODUCTION OF NUCLEOTIDE SUGARS
  申请人：DeFrees Shawn

  公开号：US20100174059A1

  公开（公告）日：2010-07-08

  The current invention provides methods (e.g., large-scale processes) for the production of nucleotide sugars, which are modified with a polymeric modifying group, such as poly(alkylene oxide) moieties (e.g., poly(ethylene glycol) or poly(propylene glycol)) moieties. A typical process of the invention includes anion exchange chromatography followed by an ultrafiltration procedure, such as tangential flow filtration. The process of the invention provides modified nucleotide sugars in unexpectedly high purity and high overall yields.