5-fluoro-6-methyl-2-methylsulfonyl-1H-benzimidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 5-fluoro-6-methyl-2-methylsulfonyl-1H-benzimidazole
• 化学式: C₉H₉FN₂O₂S
• 分子量: 228.25
• InChiKey: HRVUPEZTGNKYFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  71.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Direct AMPK activators
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US11174246B2

  公开（公告）日：2021-11-16

  Disclosed are benzimidazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein R1, R2, R3, R4, Y and X are as described herein. In certain embodiments, a compound disclosed herein activates AMPK, and can be used to treat disease by activating the AMPK pathway.

  所公开的是苯并咪唑化合物及其药物组合物和使用方法。其中一种化合物具有如下结构 及其药学上可接受的盐、原药和 N-氧化物（及其溶解物和水合物），其中 R1、R2、R3、R4、Y 和 X 如本文所述。在某些实施方案中，本文公开的化合物可激活 AMPK，并可通过激活 AMPK 途径来治疗疾病。
• DIRECT AMPK ACTIVATORS
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US20180051006A1

  公开（公告）日：2018-02-22

  Disclosed are benzimidazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein R 1 , R 2 , R 3 , R 4 , Y and X are as described herein. In certain embodiments, a compound disclosed herein activates AMPK, and can be used to treat disease by activating the AMPK pathway.