1,4-Difluoro-2-(4-methoxyphenyl)sulfanylbenzene | 1376608-67-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 1,4-Difluoro-2-(4-methoxyphenyl)sulfanylbenzene
• 英文别名: 1,4-difluoro-2-(4-methoxyphenyl)sulfanylbenzene
• CAS: 1376608-67-1
• 化学式: C₁₃H₁₀F₂OS
• 分子量: 252.285
• InChiKey: ASMPWVLCWUCSAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  S-(4-methoxyphenyl) ethanethioate 、 1,2,4-三氟苯 在 potassium carbonate 、 L-脯氨酸 、 copper(I) bromide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以41%的产率得到1,4-Difluoro-2-(4-methoxyphenyl)sulfanylbenzene
  参考文献：
  名称：

  Regioselective C–S bond formation accomplished by copper-catalyzed regioselective C–F substitution of perfluoroarenes with aryl thioacetates or benzyl thioacetate

  摘要：

  Practical and straightforward method for regioselective C-S bond formation accomplished by copper-catalyzed regioselective C-F substitution of electron-deficient perfluoroarenes with aryl thioacetates or benzyl thioacetate has been developed. Because of its high reaction efficiency, good chemoselectivity and regioselectivity, and excellent functional-group compatibility, this protocol provides a useful and operationally simple access to polyfluoroaryl thioethers used for drugs and material chemistry. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.091

文献信息

• Regioselective C–S bond formation accomplished by copper-catalyzed regioselective C–F substitution of perfluoroarenes with aryl thioacetates or benzyl thioacetate
  作者：Qizhong Zhou、Bin Zhang、Tieqi Du、Haining Gu、Huajiang Jiang、Rener Chen

  DOI：10.1016/j.tet.2012.03.091

  日期：2012.6

  Practical and straightforward method for regioselective C-S bond formation accomplished by copper-catalyzed regioselective C-F substitution of electron-deficient perfluoroarenes with aryl thioacetates or benzyl thioacetate has been developed. Because of its high reaction efficiency, good chemoselectivity and regioselectivity, and excellent functional-group compatibility, this protocol provides a useful and operationally simple access to polyfluoroaryl thioethers used for drugs and material chemistry. (C) 2012 Elsevier Ltd. All rights reserved.