2,2-dimethyl-N-(4-sulfamoyl-phenyl)-propionamide | 103826-87-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2-dimethyl-N-(4-sulfamoyl-phenyl)-propionamide
• 英文别名: 2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide
• CAS: 103826-87-5
• 化学式: C₁₁H₁₆N₂O₃S
• mdl: MFCD00095907
• 分子量: 256.326
• InChiKey: KGBTVIQRHXYTRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  97.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  三甲基乙酰氯 、 磺胺 在 sodium hydroxide 作用下， 生成 2,2-dimethyl-N-(4-sulfamoyl-phenyl)-propionamide
  参考文献：
  名称：

  碳酸酐酶抑制剂。芳香族和杂环磺酰胺对线粒体同工酶V的抑制作用。

  摘要：

  首次报道了线粒体同工酶碳酸酐酶（CA）V（鼠源性）与一系列芳香族和杂环磺酰胺的抑制作用研究。还提供了这些抑制剂对胞质同工酶CA I和CA II以及膜结合同工酶CA IV的抑制数据，以进行比较。检测到了几种低纳摩尔CA V抑制剂（KI值在4-15 nM范围内），其中大多数属于酰化的磺胺，脲基苯磺酰胺，1,3,4-噻二唑-2-磺酰胺和氨基苯甲酰胺类型。化合物。另一方面，临床上使用的抑制剂乙酰唑酰胺，甲唑酰胺，乙氧唑酰胺，多佐酰胺，布林酰胺和托吡酯是效果较差的CA V抑制剂，其抑制常数在47-63 nM范围内。一些调查过的磺胺类药物 诸如脲基苯磺酰胺和酰化磺胺酰胺等化合物对CA V的亲和力比对包括CA II在内的其他同工酶更高，这是一个了不起的结果，因为迄今为止研究的大多数化合物都能更好地抑制胞质同工酶CA II。这些结果促使我们假设，CA V的选择性抑制，或CA II和CA V的双重抑制，可能

  DOI：

  10.1021/jm031057+

文献信息

• Heat developable color photographic light-sensitive material containing
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04590154A1

  公开（公告）日：1986-05-20

  A heat developable color photographic light-sensitive material is described, comprising (1) a light-sensitive silver halide, (2) a hydrophilic binder, (3) a dye releasing compound having an ability to reduce exposed light-sensitive silver halide and capable of reacting with the exposed silver halide upon heating, thereby releasing a mobile dye, and (4) a sulfonamide compound represented by the formula R.sub.0 --SO.sub.2 NH.sub.2 wherein R.sub.0 represents an alkyl group, an alkenyl group, an alkynyl group containing at least 4 carbon atoms, an aralkyl group, an aryl group or a heterocyclic ring group, provided that the heterocyclic ring group is linked to --SO.sub.2 NH.sub.2 through a carbon atom contained in the ring thereof.

  本文描述了一种可通过加热显影的彩色感光材料，包括(1)感光银卤化物、(2)亲水性粘合剂、(3)释放染料化合物，其具有还原已曝光感光银卤化物的能力，并能在加热后与曝光的银卤化物发生反应，从而释放出可移动的染料，以及(4)磺酰胺化合物，其表示为R.sub.0--SO.sub.2NH.sub.2，其中R.sub.0表示烷基、烯基、含有至少4个碳原子的炔基、芳基烷基、芳基或杂环环基，但要求杂环环基通过其环中所含的碳原子与--SO.sub.2NH.sub.2相连。
• TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES AND METHODS OF USE THEREOF
  申请人：BABICH John W.

  公开号：US20100183509A1

  公开（公告）日：2010-07-22

  Complexes of heterocyclic radionuclides are prepared based upon ligands having substituted pyridyl and imidazolyl groups. The ligands are bifunctional, having amino acid residues that may act as a linker to a bioactive molecule, and a tridentate chelator that may complex the radionuclide. The bioactive molecule may be a peptide or somatostatin.

  基于具有取代吡啶和咪唑基团的配体制备杂环放射性核素的复合物。配体是双功能的，具有可以作为生物活性分子连接器的氨基酸残基，以及可以络合放射性核素的三齿螯合剂。生物活性分子可以是肽或生长抑素。
• Syntheses and Evaluation of Anticonvulsant Profile and Teratogenicity of Novel Amide Derivatives of Branched Aliphatic Carboxylic Acids with 4-Aminobenzensulfonamide
  作者：Naama Hen、Meir Bialer、Bogdan Wlodarczyk、Richard H. Finnell、Boris Yagen

  DOI：10.1021/jm100170w

  日期：2010.5.27

  Despite the availability of 14 new antiepileptic drugs (AEDs), about 30% of epileptic patients are not seizure-free. Consequently there is substantial need to develop new effective AEDs. A novel class of aromatic amides composed of phenylacetic acid or branched aliphatic carboxylic acids, with five to nine carbons in their carboxylic moiety, and aminobenzenesulfonamide were synthesized and evaluated in the anticonvulsant rat-maximal electroshock (MES) and subcutaneous metrazol seizure (scMet) tests. Fourteen of the synthesized amides had an anticonvulsant ED(50) of <50 mg/kg in the rat-MES test. The amides 2-methyl-N-(4-sulfamoylphenyl)butyramide (10), 2-ethyl-N-(4-sulfamoylphenyl)butyramide (11), and 3,3-dimethyl-N-(4-sulfamoylphenyl)butyramide (15) were the most potent compounds possessing MES-ED(50) values of 7.6, 9.9, and 9.4 mg/kg and remarkable protective index (PI = TD(50)/ ED(50)) values of 65.7, 50.5, and 53.2, respectively. These potent sulfanylamides caused neural tube defects only at doses markedly exceeding their effective dose. The anticonvulsant properties of these compounds make them potential candidates for further development as new, potent, and safe AEDs.
• SULFANYLAMIDE DERIVATIVES, USES THEREOF AND COMPOSITIONS COMPRISING THEM
  申请人：Bialer Meir

  公开号：US20120264827A1

  公开（公告）日：2012-10-18

  The present invention concerns a family of sulfanilamide derivatives of formula (I) as anticonvulsant agents, where R is selected from optionally substituted C 4 -C 9 alkyl, optionally substituted C 6 -C 10 aryl, optionally substituted C 6 -C 10 alkylenearyl and optionally substituted C 5 -C 10 heteroaryl; R 2 is selected from —H and optionally substituted C 1 -C 6 alkyl; each of R 3 and R 4 , independently of each other, is selected from —H, optionally substituted C 1 -C 6 alkyl, optionally substituted C 6 -C 10 aryl and optionally substituted C 5 -C 10 heteroaryl; n is 0, 1, 2, 3 or 4. The derivatives have been prepared and their anticonvulsant profile was evaluated for the control of epileptic seizures.
• [EN] COLORING COMPOSITION, COLORED CURED FILM, COLOR FILTER, MANUFACTURING METHOD OF THE SAME, AND SOLID STATE IMAGING DEVICE<br/>[FR] COMPOSITION COLORANTE, FILM DURCI COLORÉ, FILTRE COULEUR, SON PROCÉDÉ DE FABRICATION, ET DISPOSITIF D'IMAGERIE À L'ÉTAT SOLIDE
  申请人：FUJIFILM CORP

  公开号：WO2013047860A1

  公开（公告）日：2013-04-04

  To provide a coloring composition which suppresses color loss of the colored pattern to be formed, and may form a colored pattern which has excellent develop ability and heat resistance. A colored cured film which suppresses color loss of the colored pattern to be formed, and may form a colored pattern which has excellent develop ability and heat resistance, a color filter which is provided with the colored pattern, and a manufacturing method thereof are provided. A solid state imaging device which has excellent color loss resistance and heat resistance is provided. A coloring composition of the present invention includes a resin (A) having a dye structure in which a peak area occupied by a component having a molecular weight of 2000 or less is below 10% in respect to a peak area of a total molecular weight distribution of the resin (A) which is measured using gel permeation chromatography.