6-(二丙基氨基)-2-甲基-5,6,7,8-四氢-1-萘酚氢溴酸盐(1:1)

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 中文名称: 6-(二丙基氨基)-2-甲基-5,6,7,8-四氢-1-萘酚氢溴酸盐(1:1)
• 中文别名: N'-(2-氯-4-异氰酸基苯基)-2,2-二甲基丙酰肼
• 英文名称: 6-Dipropylamino-2-methyl-5,6,7,8-tetrahydro-naphthalen-1-ol; hydrobromide
• 英文别名: 6-(dipropylamino)-2-methyl-5,6,7,8-tetrahydronaphthalen-1-ol;hydron;bromide
• 化学式: BrH*C₁₇H₂₇NO
• 分子量: 342.319
• InChiKey: LJTLZOOYTANTDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.26
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  23.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(di-n-propylamino)-5-methoxy-6-methyltetralin hydrochloride 在 氢溴酸 作用下， 以 溶剂黄146 为溶剂， 反应 2.0h， 以93%的产率得到6-(二丙基氨基)-2-甲基-5,6,7,8-四氢-1-萘酚氢溴酸盐(1:1)
  参考文献：
  名称：

  Derivatives of 5-hydroxy-6-methyl-2-aminotetralin

  摘要：

  The title compounds were designed to provide semirigid congeners of m-tyramine in which the ring position ortho to the phenolic OH is blocked to metabolic hydroxylation. A sequence leading to a key synthetic intermediate, 5-methoxy-6-methyl-2-tetralone, has been developed. In animal test models for dopamine-like effects, the title compounds demonstrated qualitative and quantitative differences from the isomeric 5-methyl-6-hydroxy-2-aminotetralins and from 5,6-dihydroxy-2-aminotetralins. Two of the compounds were potent in a cat cardioaccelerator nerve assay, which involves dopamine receptors.

  DOI：

  10.1021/jm00181a010

文献信息

• Derivatives of 5-hydroxy-6-methyl-2-aminotetralin
  作者：Joseph G. Cannon、Dale L. Koble、John Paul Long、Turkiz Verimer

  DOI：10.1021/jm00181a010

  日期：1980.7

  The title compounds were designed to provide semirigid congeners of m-tyramine in which the ring position ortho to the phenolic OH is blocked to metabolic hydroxylation. A sequence leading to a key synthetic intermediate, 5-methoxy-6-methyl-2-tetralone, has been developed. In animal test models for dopamine-like effects, the title compounds demonstrated qualitative and quantitative differences from the isomeric 5-methyl-6-hydroxy-2-aminotetralins and from 5,6-dihydroxy-2-aminotetralins. Two of the compounds were potent in a cat cardioaccelerator nerve assay, which involves dopamine receptors.