methyl (1S,4S,6S)-4-(4-nitrophenyl)-6-phenyl-7-oxabicyclo[4.1.0]hept-2-ene-3-carboxylate | 1224888-51-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl (1S,4S,6S)-4-(4-nitrophenyl)-6-phenyl-7-oxabicyclo[4.1.0]hept-2-ene-3-carboxylate
• CAS: 1224888-51-0
• 化学式: C₂₀H₁₇NO₅
• 分子量: 351.359
• InChiKey: FATNPCCHMQCOKB-BJLQDIEVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  84.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  、 4-硝基查耳酮 在 caesium carbonate 作用下， 以 三氟甲苯 、 水 为溶剂， 反应 0.25h， 生成 、 methyl (1S,4S,6S)-4-(4-nitrophenyl)-6-phenyl-7-oxabicyclo[4.1.0]hept-2-ene-3-carboxylate 、
  参考文献：
  名称：

  Highly Selective Ylide-Initiated Michael Addition/Cyclization Reaction for Synthesis of Cyclohexadiene Epoxide and Vinylcyclopropane Derivatives

  摘要：

  On the basis of the reactions of camphor-derived sulfur ylide with alpha,beta-unsaturated ketone, highly efficient and selective synthesis of optically active cyclohexadiene epoxides and vinylcyclopropanes with excellent diastereoselectivities, moderate to high enantioselectivities, and yields has been achieved.

  DOI：

  10.1021/jo100306z

文献信息

• Highly Selective Ylide-Initiated Michael Addition/Cyclization Reaction for Synthesis of Cyclohexadiene Epoxide and Vinylcyclopropane Derivatives
  作者：Ben-Hu Zhu、Rui Zhou、Jun-Cheng Zheng、Xian-Ming Deng、Xiu-Li Sun、Qi Shen、Yong Tang

  DOI：10.1021/jo100306z

  日期：2010.5.21

  On the basis of the reactions of camphor-derived sulfur ylide with alpha,beta-unsaturated ketone, highly efficient and selective synthesis of optically active cyclohexadiene epoxides and vinylcyclopropanes with excellent diastereoselectivities, moderate to high enantioselectivities, and yields has been achieved.