1-isopropyl-5-(trifluoromethyl)-1,3-dihydro-2H-benzimidazole-2-thione | 209671-17-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-isopropyl-5-(trifluoromethyl)-1,3-dihydro-2H-benzimidazole-2-thione
• 英文别名: 3-propan-2-yl-6-(trifluoromethyl)-1H-benzimidazole-2-thione
• CAS: 209671-17-0
• 化学式: C₁₁H₁₁F₃N₂S
• mdl: MFCD23667404
• 分子量: 260.28
• InChiKey: UGSVUZQFISKBES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  47.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• TRPA1 modulators
  申请人：Algomedix, Inc.

  公开号：US10428049B2

  公开（公告）日：2019-10-01

  This disclosure relates to polycyclic heteroaromatic compounds useful as TRPA1 modulators, as well as compositions and methods of treating pain that include the compounds.

  本公开涉及可用作 TRPA1 调节剂的多环杂芳族化合物，以及包含该化合物的治疗疼痛的组合物和方法。
• Antibacterial Agents
  申请人：Meutermans Wim

  公开号：US20090023669A1

  公开（公告）日：2009-01-22

  The present invention, in one aspect, provides a method of inhibiting bacterial growth by contacting bacteria with an effective amount of at least one monosaccharide compound of formula (1) as described herein:
• TRPA1 MODULATORS
  申请人：Algomedix, Inc.

  公开号：US20190016701A1

  公开（公告）日：2019-01-17

  This disclosure relates to polycyclic heteroaromatic compounds useful as TRPA1 modulators, as well as compositions and methods of treating pain that include the compounds.
• TRPA1 ANTAGONISTS FOR TREATMENT OF DRY EYE, OCULAR PAIN AND INFLAMMATION
  申请人：ALGOMEDIX, INC.

  公开号：US20200179357A1

  公开（公告）日：2020-06-11

  Stable, clear, ophthalmic formulations and methods of use for an opthalmologically therapeutic effective amount of a TRPA1 antagonist, the formulation comprising buffer system, a viscosity enhancing agent, optionally a preservative, with an opthalmologically acceptable osmolarity and pH, all in an aqueous vehicle. These formulations are effective for treating ocular diseases or conditions caused by, or associated with, or accompanied by ocular pain and inflammatory processes, including, among others, dry eye N disease, uveitis, or any trauma caused by eye surgery or eye injury.
• US5883110A
  申请人：——

  公开号：US5883110A

  公开（公告）日：1999-03-16