tert-butyl N-[3-[4-[4-[[amino-[(3,5-diamino-6-chloropyrazine-2-carbonyl)amino]methylidene]amino]butyl]piperidin-1-yl]propyl]-N-[N'-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: tert-butyl N-[3-[4-[4-[[amino-[(3,5-diamino-6-chloropyrazine-2-carbonyl)amino]methylidene]amino]butyl]piperidin-1-yl]propyl]-N-[N'-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamate
• 化学式: C₂₉H₅₀ClN₁₁O₅
• 分子量: 668.2
• InChiKey: ZEMAABLAZJDFEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  46
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  243
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• Methods of reducing risk of infection from pathogens
  申请人：Johnson R. Michael

  公开号：US20050090505A1

  公开（公告）日：2005-04-28

  Prophylactic treatment methods are provided for protection of individuals and/or populations against infection from airborne pathogens. In particular, prophylactic treatment methods are provided comprising administering a sodium channel blocker or pharmaceutically acceptable salts thereof to one or more members of a population at risk of exposure to or already exposed to one or more airborne pathogens, either from natural sources or from intentional release of pathogens into the environment.

  提供了预防性治疗方法，以保护个人和/或人群免受空气传播病原体的感染。特别是，提供了预防性治疗方法，包括向处于接触或已经接触到一个或多个空气传播病原体的风险人群中的一个或多个成员，从自然来源或故意释放病原体进入环境中，给予钠通道阻滞剂或其药学上可接受的盐。
• CYCLIC PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
  申请人：JOHNSON R. Michael

  公开号：US20080103148A1

  公开（公告）日：2008-05-01

  The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.

  本发明涉及钠通道阻滞剂。本发明还包括使用这些创新的钠通道阻滞剂的各种治疗方法。
• EP1670474A4
  申请人：——

  公开号：EP1670474A4

  公开（公告）日：2008-08-06
• [EN] CYCLIC PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS<br/>[FR] BLOQUEURS DU CANAL SODIQUE A PYRAZINOYL-GUANIDINE CYCLIQUE
  申请人：PARION SCIENCES INC

  公开号：WO2005016879A2

  公开（公告）日：2005-02-24

  The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.