(4S,5S)-2-(2-Thienyl)-1,3-dioxolane-4,5-dicarboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧戊环
• 英文名称: (4S,5S)-2-(2-Thienyl)-1,3-dioxolane-4,5-dicarboxamide
• 英文别名: (4S,5S)-2-thiophen-2-yl-1,3-dioxolane-4,5-dicarboxamide
• 化学式: C₉H₁₀N₂O₄S
• 分子量: 242.255
• InChiKey: GFJLDQMLQSIUPB-WDSKDSINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  133
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (4S,5S)-2-(2-Thienyl)-1,3-dioxolane-4,5-dicarboxamide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以55.2%的产率得到
  参考文献：
  名称：

  Synthesis of novel heptaplatin derivatives and evaluation of their ability to inhibit proliferation of cancer cell lines

  摘要：

  A series of novel heptaplatin derivatives were synthesized and evaluated for their ability to inhibit growth of two cancer cell lines: human colon carcinoma cell line HCT-8 and human hepatocarcinoma cell line Bel-7402. Majority of the synthesized compounds demonstrated superior activity against cancer cell lines compared to heptaplatin. Specifically, compounds 5a and 5b (5 A mu g/mL) had more pronounced efficacy against the HCT-8 cell line while 6b and 6c (0.5 A mu g/mL) had higher efficacy against Bel-7402 cell line.

  DOI：

  10.1134/s1070363216040319
• 作为产物：
  描述：

  在 氨 作用下， 以 乙醇 为溶剂， 反应 3.5h， 生成 (4S,5S)-2-(2-Thienyl)-1,3-dioxolane-4,5-dicarboxamide
  参考文献：
  名称：

  Synthesis of novel heptaplatin derivatives and evaluation of their ability to inhibit proliferation of cancer cell lines

  摘要：

  A series of novel heptaplatin derivatives were synthesized and evaluated for their ability to inhibit growth of two cancer cell lines: human colon carcinoma cell line HCT-8 and human hepatocarcinoma cell line Bel-7402. Majority of the synthesized compounds demonstrated superior activity against cancer cell lines compared to heptaplatin. Specifically, compounds 5a and 5b (5 A mu g/mL) had more pronounced efficacy against the HCT-8 cell line while 6b and 6c (0.5 A mu g/mL) had higher efficacy against Bel-7402 cell line.

  DOI：

  10.1134/s1070363216040319