2-Isopropyl-N,6-dimethylpyrimidin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-Isopropyl-N,6-dimethylpyrimidin-4-amine
• 英文别名: N,6-dimethyl-2-propan-2-ylpyrimidin-4-amine
• 化学式: C₉H₁₅N₃
• 分子量: 165.24
• InChiKey: XMHOKWKIIVOLIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] THIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND THEIR USE AS TYK2 KINASE INHIBITORS<br/>[FR] COMPOSÉS DE THIAZOLOPYRIDINE, COMPOSITIONS ET LEUR UTILISATION COMME INHIBITEURS DE LA KINASE TYK2
  申请人：HOFFMANN LA ROCHE

  公开号：WO2015091584A1

  公开（公告）日：2015-06-25

  Provided are thiazolopyridine compounds that are inhibitors of TYK2 kinase, compositions containing these compounds and methods for treating diseases mediated by TYK2 kinase. In particular, provided are compounds of Formula (I), (II) or (III), stereoisomers, tautomers, solvates, prodrugs or pharmaceutically acceptable salts thereof, where X, R0, R1, R2, R3, R4 and R5 are defined herein, pharmaceutical compositions comprising the compound and a pharmaceutically acceptable carrier, adjuvant or vehicle, methods of using the compound or composition in therapy, for example, for treating a disease or condition mediated by TYK2 kinase in a patient.

  提供了一些噻唑吡啶化合物，这些化合物是TYK2激酶的抑制剂，包含这些化合物的组合物以及治疗由TYK2激酶介导的疾病的方法。具体来说，提供了符合Formula (I)、(II)或(III)的化合物，其立体异构体、互变异构体、溶剂合物、前药或其药用可接受的盐，其中X、R0、R1、R2、R3、R4和R5在此有定义，包括该化合物和药用可接受的载体、辅料或溶剂的药物组合物，使用该化合物或组合物进行治疗的方法，例如，用于治疗患有TYK2激酶介导的疾病或症状的患者。
• Pyrazole compounds useful as protein kinase inhibitors
  申请人：Bebbington David

  公开号：US20070270444A1

  公开（公告）日：2007-11-22

  This invention describes novel pyrazole compounds of formula IV: wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R x and R y are independently selected from T-R 3 , or taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered ring having 1-3 ring heteroatoms selected from oxygen, sulfur, or nitrogen; and R 2 , R 2′ , T, and R 3 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.

  该发明描述了式IV的新型吡唑化合物： 其中环D为从芳基，杂芳基，杂环基或碳环基中选择的5-7成员单环或8-10成员双环；Rx和Ry独立地选择自T-R3，或者与它们之间的原子结合形成融合的、不饱和的或部分不饱和的、具有1-3个环杂原子的5-8成员环；而R2，R2'，T和R3如说明书所述。这些化合物可用作蛋白激酶抑制剂，特别是作为aurora-2和GSK-3的抑制剂，用于治疗癌症、糖尿病和阿尔茨海默病等疾病。
• Material Having Antibacterial and Antifungal Properties
  申请人：Herbst Heinz

  公开号：US20090269379A1

  公开（公告）日：2009-10-29

  A garment or footwear based on a synthetic thermoplastic polymer material containing (a) an antibacterial agent selected from phenolic antimicrobial compounds of the formula (I) wherein n is 0 or preferably 1, R 1 and R 2 are hydrogen or chloro, R 3 is hydroxyl or preferably hydrogen, R 4 , R 5 and R 6 are hydrogen or chloro, R 7 is hydroxyl, and X is a direct bond, —NHCONH—, —CH 2 — or preferably —O—; and (b) an antifungal agent selected from benzimidazole fungicides, triazoles, 2,4-bis(alkylamino)pyrimidines, isothiazolinon fungicides, 10,10′-oxy-bis-phenoxyarsen, zinc pyrithione has good antimicrobial properties.
• US7691853B2
  申请人：——

  公开号：US7691853B2

  公开（公告）日：2010-04-06