2-(2-hydroxy-benzylamino)-2-hydroxymethyl-propane-1,3-diol | 211056-78-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-hydroxy-benzylamino)-2-hydroxymethyl-propane-1,3-diol
• 英文别名: H5hbhpd；2-((2-Hydroxybenzyl)amino)-2-(hydroxymethyl)propane-1,3-diol；2-(hydroxymethyl)-2-[(2-hydroxyphenyl)methylamino]propane-1,3-diol
• CAS: 211056-78-9
• 化学式: C₁₁H₁₇NO₄
• 分子量: 227.26
• InChiKey: ZHQKQWJEENBEQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  93
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(2-hydroxy-benzylamino)-2-hydroxymethyl-propane-1,3-diol 、 氧化三乙氧基钒 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Rao, Chebrolu P.; Sreedhara, Alavattam; Rao, P. Venkateswara, Journal of the Chemical Society, Dalton Transactions, 1998, # 14, p. 2383 - 2393

  摘要：

  DOI：
• 作为产物：
  描述：

  2-[(2-羟基苄亚基)氨基]-2-(羟基甲基)-1,3-丙烷二醇 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以90%的产率得到2-(2-hydroxy-benzylamino)-2-hydroxymethyl-propane-1,3-diol
  参考文献：
  名称：

  Rao, Chebrolu P.; Sreedhara, Alavattam; Rao, P. Venkateswara, Journal of the Chemical Society, Dalton Transactions, 1998, # 14, p. 2383 - 2393

  摘要：

  DOI：

文献信息

• Recognition of oxovanadium(V) species and its separation from other metal species through selective complexation by some acyclic ligands
  作者：Chebrolu P. Rao、A. Sreedhara、P.Venkateswara Rao、N.K. Lokanath、M.a. Sridhar、J.S. Prasad、Kari Rissanenm

  DOI：10.1016/s0277-5387(98)00298-8

  日期：1998.12

  Acyclic molecules possessing -OH (phenoxo and alkoxo type) groups and imine or amine moieties have been developed to sense the specific preference for VO3+ species. These molecules also showed a capability to quantitatively separate oxovanadium(V) species from a reaction mixture containing metal species of V, Mo, U, Fe, and Mn ions in solution. A cascade quantitative separation of VO3+ followed by cis - MoO22+ followed by trans - UO22+ species is demonstrated from their mixture. Synthesis and structural details of ore-species of vanadium molybdenum and uranium are also discussed. Factors influencing the complexation of these molecules towards oxo metal species of V, Mo and U are also addressed. (C) 1998 Elsevier Science Ltd. All rights reserved.
• Tetranuclear mixed-valence Co(II/III) and binuclear Ni(II) complexes incorporating hydroxyl-rich ligand: Syntheses, structures and magnetic properties
  作者：Su-Yun Zhang、Bin Xu、Lina Zheng、Wenqian Chen、Yahong Li、Wu Li

  DOI：10.1016/j.ica.2010.11.038

  日期：2011.2

  Three complexes of composition [(Co2Co2III)-Co-II(H(2)hbhpd)(2)(H(4)hbhpd)(2)(H2O)(2)]Cl-2(CH3OH)(4) (1), [(Co2Co2III)-Co-II (H(2)hbhpd)(2)(H(4)hbhpd)(2)(H2O)(2)](NO3)(2)(CH3OH)(4) (2) and [Ni-2(H(4)hbhpd)(2)(NO3)](NO3)(CH3OH)(1.5) (3) (H(5)hbhpd = 2-(2-hydroxy-benzylamino)-2-hydroxymethyl-propane-1,3-diol) have been synthesized and their structures have been characterized. Complexes 1 and 2 are mixed-valence cobalt clusters and display face-sharing monovacant dicubane structures. In the complexes 1 and 2, one of the three alkyl hydroxyl groups of H(5)hbhpd ligand is deprotonated instead of deprotonation of phenyl hydroxyl group; thus monoanionic H(4)hbhpd ligand displays novel eta(3), eta(1), eta(1), mu(3) coordination mode. Complex 3 is binuclear, and the two metal centers of 3 are bridged by two deprotonated phenyl hydroxyl oxygen atoms and iso-orthogonalized by a nitrato group in eta(1)eta(1)-O,O' coordination fashion. Variable-temperature solid-state dc magnetization studies have been performed in the temperature range 2-300 K for compounds 1 and 3. Antiferromagnetic interactions were determined for 1 and ferromagnetic couplings were found for 3. (C) 2010 Elsevier B.V. All rights reserved.
• Tetranuclear nickel(II) complex with tripodal hydroxyl ligand functionalized by additional salicylaldehyde donor pendant: Synthesis, crystal structure and magnetic property
  作者：Jing-Wen Ran、Su-Yun Zhang、Bin Xu、Yuanzhi Xia、Dong Guo、Jing-Yan Zhang、Yahong Li

  DOI：10.1016/j.inoche.2007.10.014

  日期：2008.1

  The tetranuclear cubane-like [Ni-4(H(3)hbhpd)(4)] center dot 4H(2)O complex has been prepared by the reaction of nickel(II) acetate with H(5)hbhpd, where H5hbhpd is 2(2-hydroxy-benzylamino)-2-hydroxymethyl-propane-1,3-diol. The X-ray diffraction analysis of the complex showed a Ni4O4 cubane arrangement of four nickel atoms. Magnetic studies indicate ferromagnetic behavior for the complex. The magnetic data were fitted and the parameters are given as g = 2.21, J(1) = 0.32, J(2) = 8.27, D = -0.05 cm(-1). (c) 2007 Elsevier B.V. All rights reserved.
• US6403054B1
  申请人：——

  公开号：US6403054B1

  公开（公告）日：2002-06-11
• Rao, Chebrolu P.; Sreedhara, Alavattam; Rao, P. Venkateswara, Journal of the Chemical Society, Dalton Transactions, 1998, # 14, p. 2383 - 2393
  作者：Rao, Chebrolu P.、Sreedhara, Alavattam、Rao, P. Venkateswara、Verghese, M. Bindu、Rissanen, Kari、Kolehmainen, Erkki、Lokanath、Sridhar、Prasad, J. Sashidhara

  DOI：——

  日期：——