2-bromo-6-fluorobenzene-1-sulfonyl chloride | 886762-59-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-bromo-6-fluorobenzene-1-sulfonyl chloride
• 英文别名: 2-Bromo-6-fluorobenzenesulphonyl chloride；2-bromo-6-fluorobenzenesulfonyl chloride
• CAS: 886762-59-0
• 化学式: C₆H₃BrClFO₂S
• mdl: MFCD07368673
• 分子量: 273.51
• InChiKey: XTODIZFNGWAEAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-bromo-6-fluorobenzene-1-sulfonyl chloride 、 6-((4-(4-(3-amino-2-fluorophenyl)-2-(bicyclo[1.1.1]pentan-1-yl)thiazol-5-yl)pyrimidin-2-yl)amino)-2-thiaspiro[3.3]heptane 2,2-dioxide 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 N-(3-(2-(bicyclo[1.1.1]pentan-1-yl)-5-(2-((2,2-dioxido-2-thiaspiro[3.3]heptan-6-yl)amino)pyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2-bromo-6-fluorobenzenesulfonamide
  参考文献：
  名称：

  SULFONAMIDO DERIVATIVES AS CYCLIN-DEPENDENT KINASE 2 INHIBITORS

  摘要：

  The present disclosure provides certain sulfonamido derivatives that are Cyclin-dependent kinase 2 (CDK2) inhibitors of Formula (I): for the treatment of diseases treatable by inhibition of CDK2. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

  公开号：

  US20230303509A1
• 作为产物：
  描述：

  2-溴-6-氟苯胺 在 氯化亚砜 、 copper(l) chloride 、 sodium nitrite 作用下， 以 水 为溶剂， 生成 2-bromo-6-fluorobenzene-1-sulfonyl chloride
  参考文献：
  名称：

  SULFONAMIDO DERIVATIVES AS CYCLIN-DEPENDENT KINASE 2 INHIBITORS

  摘要：

  The present disclosure provides certain sulfonamido derivatives that are Cyclin-dependent kinase 2 (CDK2) inhibitors of Formula (I): for the treatment of diseases treatable by inhibition of CDK2. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

  公开号：

  US20230303509A1

文献信息

• FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20190031600A1

  公开（公告）日：2019-01-31

  Provided is a fluorine atom-containing compound represented by formula (1) below (In the formula, Z represents a predetermined divalent group, each Ar independently represents a predetermined aromatic ring-containing group, and each Ar F independently represents a predetermined fluorine atom-containing aryl group).

  提供的是下面公式（1）所代表的含氟原子的化合物（在公式中，Z代表预定的二价基团，每个Ar独立代表预定的含芳香环的基团，每个ArF独立代表预定的含氟原子的芳基基团）。
• IMAGING TUMOR GLYCOLYSIS BY NON-INVASIVE MEASUREMENT OF PYRUVATE KINASE M2
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20180043040A1

  公开（公告）日：2018-02-15

  The present disclosure provides a positron emission tomography (PET)-detectable 1-((2-fluoro-6-[ 18 F]fluorophenyl)sulfonyl)-4-((4-methoxyphenyl)sulfonyl)piperazine ([ 18 F]DASA-23) probe that can selectively bind to the pyruvate kinase variant M2 (PKM2) found in cancer cells, such as of human glioma. Given the importance of PKM2 in the regulation of tumor metabolism, there is an on-going need to non-invasively measure its expression through the development of PKM2-specific radiopharmaceuticals. Precursors useful for the synthesis of the radiolabeled [ 18 F]DASA-23-PKM2-specific probe and related compounds, and their methods of synthesis, are provided. Since the half-life of the 18 F isotope is approximately 110 min, it is advantageous for a practitioner to attach the radionuclide to the precursor shortly before administration. Therefore, a precursor compound suitable for receiving the radionuclide and capable of specifically binding to the PKM2 variant can be provided.

  本公开提供了一种正电子发射断层扫描（PET）可检测的1-（（2-氟-6-[18F]氟苯基）磺酰基）-4-（（4-甲氧基苯基）磺酰基）哌嗪（[18F]DASA-23）探针，该探针可以选择性地结合于癌细胞中发现的丙酮酸激酶变异体M2（PKM2），例如人脑胶质瘤。鉴于PKM2在肿瘤代谢调节中的重要性，需要通过开发PKM2特异性放射性药物来非侵入性地测量其表达。提供了用于合成放射性标记的[18F]DASA-23-PKM2特异性探针和相关化合物的有用前体及其合成方法。由于18F同位素的半衰期约为110分钟，因此对于从业者来说，在给药前不久将放射性核素附加到前体上是有利的。因此，可以提供一种适用于接收放射性核素并能够特异性结合于PKM2变异体的前体化合物。
• Fluorine atom-containing compound and use thereof
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US10336686B2

  公开（公告）日：2019-07-02

  Provided is a fluorine atom-containing compound represented by formula (1) below (In the formula, Z represents a predetermined divalent group, each Ar independently represents a predetermined aromatic ring-containing group, and each ArF independently represents a predetermined fluorine atom-containing aryl group).

  本发明提供了由下式（1）表示的含氟原子化合物 (式中，Z 代表预定的二价基团，每个 Ar 独立地代表预定的含芳香环基团，每个 ArF 独立地代表预定的含氟原子的芳基）。
• Imaging tumor glycolysis by non-invasive measurement of pyruvate kinase M2
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US10675366B2

  公开（公告）日：2020-06-09

  The present disclosure provides a positron emission tomography (PET)-detectable 1-((2-fluoro-6-[18F]fluorophenyl)sulfonyl)-4-((4-methoxyphenyl)sulfonyl)piperazine ([18F]DASA-23) probe that can selectively bind to the pyruvate kinase variant M2 (PKM2) found in cancer cells, such as of human glioma. Given the importance of PKM2 in the regulation of tumor metabolism, there is an on-going need to non-invasively measure its expression through the development of PKM2-specific radiopharmaceuticals. Precursors useful for the synthesis of the radiolabeled [18F]DASA-23-PKM2-specific probe and related compounds, and their methods of synthesis, are provided. Since the half-life of the 18F isotope is approximately 110 min, it is advantageous for a practitioner to attach the radionuclide to the precursor shortly before administration. Therefore, a precursor compound suitable for receiving the radionuclide and capable of specifically binding to the PKM2 variant can be provided.

  本公开提供了一种正电子发射断层扫描（PET）可检测的1-((2-氟-6-[18F]氟苯基)磺酰基)-4-((4-甲氧基苯基)磺酰基)哌嗪（[18F]DASA-23）探针，该探针可选择性地与癌细胞（如人类胶质瘤）中的丙酮酸激酶变体M2（PKM2）结合。鉴于 PKM2 在调节肿瘤代谢中的重要性，目前需要通过开发 PKM2 特异性放射性药物来非侵入性地测量其表达。本文提供了用于合成放射性标记的[18F]DASA-23-PKM2 特异性探针和相关化合物的前体及其合成方法。由于 18F 同位素的半衰期约为 110 分钟，因此对于医生来说，在给药前不久将放射性核素附着在前体上是非常有利的。因此，可以提供一种适合接受放射性核素并能与 PKM2 变异体特异性结合的前体化合物。
• CN117088867
  申请人：——

  公开号：——

  公开（公告）日：——