S-{3-isopropoxy-2-[(trimethylsilyl)oxy]propyl} benzenecarbothioate | 1430238-01-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: S-{3-isopropoxy-2-[(trimethylsilyl)oxy]propyl} benzenecarbothioate
• 英文别名: S-(3-propan-2-yloxy-2-trimethylsilyloxypropyl) benzenecarbothioate
• CAS: 1430238-01-9
• 化学式: C₁₆H₂₆O₃SSi
• 分子量: 326.532
• InChiKey: XZYZRROKCRPTGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.21
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  60.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  异丙基缩水甘油醚 、 硫代苯甲酸 在 silica gel 作用下， 以 neat (no solvent) 为溶剂， 反应 1.5h， 生成 S-{3-isopropoxy-2-[(trimethylsilyl)oxy]propyl} benzenecarbothioate
  参考文献：
  名称：

  One-Pot Tandem Synthesis of β-Trimethylsilyloxy Thioesters from Thioacids, Epoxides, and HMDS Catalyzed by Silica Gel Under Solvent-Free Conditions

  摘要：

  A procedure for one-pot preparation of beta-trimethylsilyloxy thioesters from epoxides, thioacids, and hexamethyl disilazane (HMDS) in the presence of silica gel under solvent-free condition was developed. The desired silylated products were isolated in good to excellent yields after silica-gel column chromatography.Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.

  DOI：

  10.1080/00397911.2012.667183

文献信息

• One-Pot Tandem Synthesis of <font>β</font>-Trimethylsilyloxy Thioesters from Thioacids, Epoxides, and HMDS Catalyzed by Silica Gel Under Solvent-Free Conditions
  作者：Mohammad Abbasi

  DOI：10.1080/00397911.2012.667183

  日期：2013.7.3

  A procedure for one-pot preparation of beta-trimethylsilyloxy thioesters from epoxides, thioacids, and hexamethyl disilazane (HMDS) in the presence of silica gel under solvent-free condition was developed. The desired silylated products were isolated in good to excellent yields after silica-gel column chromatography.Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.