N-([1,1'-biphenyl]-2-yl)-N-methylformamide | 1290540-69-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-([1,1'-biphenyl]-2-yl)-N-methylformamide
• 英文别名: N-[1,1a(2)-Biphenyl]-2-yl-N-methylformamide；N-methyl-N-(2-phenylphenyl)formamide
• CAS: 1290540-69-0
• 化学式: C₁₄H₁₃NO
• 分子量: 211.263
• InChiKey: UHTFHCGRSIISET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  二氟溴乙酸乙酯 、 N-甲基联苯-2-胺 在 水 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以37%的产率得到N-([1,1'-biphenyl]-2-yl)-N-methylformamide
  参考文献：
  名称：

  An efficient method for the N-formylation of amines under catalyst- and additive-free conditions

  摘要：

  A simple catalyst- and additive-free method for the N-formylation of amines has been developed. The advantages of this protocol include a wide range of functional group tolerance, high efficiency and a lack of required extra promoters under mild conditions. This convenient strategy will provide a facile synthesis towards N-formamide natural products and pharmaceutical derivatives. A mechanism that involves difluorocarbene is proposed for this reaction. (C) 2019 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2019.03.071

文献信息

• An efficient method for the N-formylation of amines under catalyst- and additive-free conditions
  作者：Zhuo-Wei Xu、Wen-Yi Xu、Xiao-Jun Pei、Fei Tang、Yi-Si Feng

  DOI：10.1016/j.tetlet.2019.03.071

  日期：2019.5

  A simple catalyst- and additive-free method for the N-formylation of amines has been developed. The advantages of this protocol include a wide range of functional group tolerance, high efficiency and a lack of required extra promoters under mild conditions. This convenient strategy will provide a facile synthesis towards N-formamide natural products and pharmaceutical derivatives. A mechanism that involves difluorocarbene is proposed for this reaction. (C) 2019 Elsevier Ltd. All rights reserved.