phenyl 2-acetoxy-2-phenyl acetate | 1100171-39-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: phenyl 2-acetoxy-2-phenyl acetate
• 英文别名: Phenyl 2-acetyloxy-2-phenylacetate
• CAS: 1100171-39-8
• 化学式: C₁₆H₁₄O₄
• 分子量: 270.285
• InChiKey: FYZUWJGEKAIRCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-phenyl-2-oxazolidinone 、 phenyl 2-acetoxy-2-phenyl acetate 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 [(1R)-2-oxo-2-[(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]-1-phenylethyl] acetate 、
  参考文献：
  名称：

  Investigations into the parallel kinetic resolution of acetyl mandelic acid

  摘要：

  The resolution of a series of active esters (derived from acetyl mandelic acid) using an equimolar combination of quasi-enantiomeric oxazolidin-2-ones is discussed. The levels of diastereoselectivity and the facial selectivity were found to be dependent on the structural nature of the pro-leaving group. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.10.062

文献信息

• [EN] AMINO METHYL IMIDAZOLES AS C5A RECEPTOR MODULATORS<br/>[FR] AMINOMETHYL IMIDAZOLES EN TANT QUE MODULATEURS DE RECEPTEURS C5A
  申请人：NEUROGEN CORP

  公开号：WO2004018460A1

  公开（公告）日：2004-03-04

  Amino methyl imidazoles of Formula (I) are provided: wherein R, Rl, R2, R3, R4, R5, and R6 are defined herein.Such compounds are ligands of C5a receptors. Preferred compounds of Formula (I) bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. Additionally, this invention provides labeled amino methyl imidazoles compounds, which are useful as probes for the localization of C5a receptors.

  本发明提供了化学式（I）中的氨甲基咪唑衍生物：其中R，Rl，R2，R3，R4，R5和R6如本文所定义。这些化合物是C5a受体的配体。化学式（I）的优选化合物具有高亲和力与C5a受体结合，并在C5a受体上表现为中性拮抗剂或逆激动剂活性。本发明还涉及包含这些化合物的制药组合物。它进一步涉及使用这些化合物治疗各种炎症、心血管和免疫系统疾病。此外，本发明提供了标记的氨甲基咪唑衍生物化合物，它们可用作定位C5a受体的探针。
• Amino methyl imidazoles as C5a receptor modulators
  申请人：Neurogen Corporation

  公开号：US20040082577A1

  公开（公告）日：2004-04-29

  Amino methyl imidazoles of Formula I are provided: 1 wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. Additionally, this invention provides labeled amino methyl imidazoles compounds, which are useful as probes for the localization of C5a receptors.

  本发明提供了式I的氨甲基咪唑化合物：1其中R，R1，R2，R3，R4，R5和R6的定义如本文所述。此类化合物是C5a受体的配体。式I的优选化合物具有高亲和力结合C5a受体，并在C5a受体上表现为中性拮抗剂或逆激动剂活性。本发明还涉及包含此类化合物的制药组合物。此外，本发明还涉及标记的氨甲基咪唑化合物，其可用作C5a受体定位的探针。本发明还提供了使用这类化合物治疗各种炎症、心血管和免疫系统疾病的方法。
• Oligosaccharide aldonic acids and their topical use
  申请人：——

  公开号：US20020028227A1

  公开（公告）日：2002-03-07

  Compositions comprising oligosaccharide aldonic acids are useful for general care, as well as for treatment and prevention, of various cosmetic conditions and dermatological disorders, including those associated with intrinsic and/or extrinsic aging, as well as with changes or damage caused by extrinsic factors; general care, as well as treatment and prevention of diseases and conditions, of the oral, and vaginal mucosa; for general oral care, as well as treatment and prevention of oral and gum diseases; and for wound healing of the skin. Compositions comprising oligosaccharide aldonic acids may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

  含有寡糖醛酸的组合物可用于一般护理、治疗和预防各种化妆品状况和皮肤疾病，包括与内在和/或外在衰老有关的疾病和疾病以及由外在因素引起的变化或损伤；一般护理、治疗和预防口腔和阴道粘膜的疾病和状况；一般口腔护理，以及治疗和预防口腔和牙龈疾病；以及用于皮肤伤口愈合。含有寡糖醛酸的组合物还可以包含化妆品、药品或其他局部剂以增强或创造协同效应。
• Amino methyl imidazoles and related compounds as C5a receptor modulators
  申请人：Thurkauf Andrew

  公开号：US20070212297A1

  公开（公告）日：2007-09-13

  Amino methyl imidazoles of Formula I are provided: wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. Additionally, this invention provides labeled amino methyl imidazoles compounds, which are useful as probes for the localization of C5a receptors.

  提供了式I的氨甲基咪唑：其中R，R1，R2，R3，R4，R5和R6如本文所定义。这些化合物是C5a受体的配体。式I的优选化合物以高亲和力结合C5a受体，并在C5a受体上表现出中性拮抗剂或反向激动剂活性。本发明还涉及包含这种化合物的制药组合物。它还涉及使用这种化合物治疗各种炎症，心血管和免疫系统疾病。此外，本发明提供了标记的氨甲基咪唑化合物，可用作C5a受体定位的探针。
• Oligosaccharide Aldonic Acids and Their Topical Use
  申请人：Yu J. Ruey

  公开号：US20080090772A1

  公开（公告）日：2008-04-17

  Compositions comprising oligosaccharide aldonic acids are useful for general care, as well as for treatment and prevention, of various cosmetic conditions and dermatological disorders, including those associated with intrinsic and/or extrinsic aging, as well as with changes or damage caused by extrinsic factors; general care, as well as treatment and prevention of diseases and conditions, of the oral, and vaginal mucosa; for general oral care, as well as treatment and prevention of oral and gum diseases; and for wound healing of the skin. Compositions comprising oligosaccharide aldonic acids may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

  含寡糖醛酸的组合物可用于一般护理，以及用于治疗和预防各种化妆品状况和皮肤疾病，包括与内在和/或外在衰老有关的状况，以及由外在因素引起的变化或损伤；一般护理，以及治疗和预防口腔和阴道粘膜的疾病和状况；用于一般口腔护理，以及治疗和预防口腔和牙龈疾病；以及用于皮肤伤口愈合。含寡糖醛酸的组合物还可以包含化妆品、药品或其他局部制剂，以增强或创造协同作用。