1,2-bis-(4'-hydroxy-3'-methoxyphenyl)ethanol | 113932-04-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1,2-bis-(4'-hydroxy-3'-methoxyphenyl)ethanol
• 英文别名: 4-[2-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]-2-methoxyphenol
• CAS: 113932-04-0
• 化学式: C₁₆H₁₈O₅
• 分子量: 290.316
• InChiKey: VUKQUZSAXWXZHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  79.2
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 1,2-bis-(4'-hydroxy-3'-methoxyphenyl)ethanol 在 吡啶 作用下， 生成 Acetic acid 1,2-bis-(4-acetoxy-3-methoxy-phenyl)-ethyl ester
  参考文献：
  名称：

  Singh, Sheo Bux; Pettit, George R., Synthetic Communications, 1987, vol. 17, # 7, p. 877 - 892

  摘要：

  DOI：
• 作为产物：
  描述：

  O-tert-butyldimethylsilylvanillin 在 sodium tetrahydroborate 、 三甲基氯硅烷 、 四丁基氟化铵 、 sodium 、 lithium 、 lithium bromide 作用下， 以 四氢呋喃 、 乙醇 、 乙腈 为溶剂， 反应 11.58h， 生成 1,2-bis-(4'-hydroxy-3'-methoxyphenyl)ethanol
  参考文献：
  名称：

  Singh, Sheo Bux; Pettit, George R., Synthetic Communications, 1987, vol. 17, # 7, p. 877 - 892

  摘要：

  DOI：

文献信息

• Composition comprising at least one 2-(3,4-disubstituted)phenyl-1-(3,4-disubstituted)phenyl-1-hydroxyethane for preventing and/or treating the signs of ageing of the skin
  申请人：L'OREAL

  公开号：US10357440B2

  公开（公告）日：2019-07-23

  The present invention relates to the cosmetic use, in a composition containing a physiologically acceptable medium, of at least one compound of formula (I) in which: —R3 means a hydrogen atom or a hydroxyl radical, —R1 and R2 mean, independently of each other, a hydrogen atom, a linear or branched C1-C6 alkyl radical; a benzyl radical; a linear or branched C1-C6 alkylcarbonyl radical not conjugated with the carbonyl; or a linear or branched C1-C6 alkoxycarbonyl radical, and/or of an isomer and/or of a salt and/or of a solvate of said compound of formula (1), for preventing and/or treating the signs of ageing of the skin and its appendages.

  本发明涉及至少一种式(I)化合物在含有生理上可接受的介质的组合物中的化妆品用途，在式(I)中：-R3指氢原子或羟基，-R1和R2各自指氢原子、直链或支链C1-C6烷基；苄基；未与羰基共轭的直链或支链C1-C6烷基羰基；或直链或支链C1-C6烷氧基羰基，和/或所述式（1）化合物的异构体和/或盐和/或溶液，用于预防和/或治疗皮肤及其附属物的老化迹象。
• 1-(3,4-DISUBSTITUTED)PHENYL-2-(3,4-DISUBSTITUTED)PHENYLETHANE COMPOUNDS AND USE THEREOF
  申请人：L'Oréal

  公开号：EP3237366B1

  公开（公告）日：2019-09-11
• [EN] 1-(3,4-DISUBSTITUTED)PHENYL-2-(3,4-DISUBSTITUTED)PHENYLETHANE COMPOUNDS AND USE THEREOF<br/>[FR] COMPOSÉS PHÉNYL 1-(3,4-DISUBSTITUÉS) PHÉNYLÉTHANE 2-(3,4-DISUBSTITUÉS) ET LEUR UTILISATION
  申请人：OREAL

  公开号：WO2016102472A1

  公开（公告）日：2016-06-30

  The present invention relates to the cosmetic use, in a composition containing a physiologically acceptable medium, of at least one compound of formula (1): in which: - R1 means a hydrogen atom, a linear or branched C1-C6 alkyl radical; a benzyl radical; a linear or branched C1-C6 alkylcarbonyl radical not conjugated with the carbonyl; or a linear or branched C1-C6 alkoxycarbonyl, - R2 means a hydrogen atom, a hydroxy! radical, a linear or branched C1-C6 alkoxy radical; a benzyloxy radical; a linear or branched C1-C6 alkylcarbonyloxy radical not conjugated with the carbonyl, or a linear or branched C1-C6 alkoxycarbonyloxy radical, - R3 means a hydrogen atom or a hydroxy! radical, on the understanding that R3 means a hydrogen atom only in the cases where R2 also means a hydrogen atom, and/or of an isomer and/or of a salt and/or of a solvate of the compound of formula (I), for protecting the skin and/or skin appendages against oxidative stress caused by exposure to UV radiation.