2-Hydroxy-3,5-bis[(4-hydroxy-2-methyl-5-sulfophenyl)methyl]-4-methylbenzenesulfonic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 2-Hydroxy-3,5-bis[(4-hydroxy-2-methyl-5-sulfophenyl)methyl]-4-methylbenzenesulfonic acid
• 化学式: C₂₃H₂₄O₁₂S₃
• mdl: MFCD00869035
• 分子量: 588.6
• InChiKey: ACZKMKGNTMOPBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.217
• 拓扑面积：
  249
• 氢给体数：
  6
• 氢受体数：
  12

文献信息

• Beta-O/S/N fatty acid based compounds as antibacterial and antiprotozoal agents
  申请人：Ludwig-Maximilians-Universität München

  公开号：EP2601941A1

  公开（公告）日：2013-06-12

  The present invention relates to beta-O/S/N fatty acids and derivatives thereof, in particular the compounds of formula (I) as described and defined herein, and their pharmaceutical use, including their use in the treatment or prevention of bacterial as well as protozoan infections, in particular the treatment or prevention of infections with Gram-positive and/or Gram-negative bacteria and infectious diseases caused by and/or related to Gram-positive and/or Gram-negative bacteria. The invention further relates to the use of these compounds for preventing or eliminating biofilms.

  本发明涉及beta-O/S/N脂肪酸及其衍生物，特别是如本文所述和定义的公式(I)化合物，及其医药用途，包括用于治疗或预防细菌以及原生动物感染，特别是治疗或预防革兰氏阳性细菌和/或革兰氏阴性细菌引起的感染和传染病以及与之相关的感染和传染病。该发明还涉及这些化合物用于预防或消除生物膜。
• [EN] BETA-O/S/N FATTY ACID BASED COMPOUNDS AS ANTIBACTERIAL AND ANTIPROTOZOAL AGENTS<br/>[FR] COMPOSÉS À BASE DE BÊTA-O/S/N ACIDES GRAS EN TANT QU'AGENTS ANTIBACTÉRIENS ET ANTI-PROTOZOAIRES
  申请人：UNIV MUENCHEN L MAXIMILIANS

  公开号：WO2013083724A1

  公开（公告）日：2013-06-13

  The present invention relates to beta-O/S/N fatty acids and derivatives thereof, in particular the compounds of formula (I) as described and defined herein, and their pharmaceutical use, including their use in the treatment or prevention of bacterial as well as protozoan infections, in particular the treatment or prevention of infections with Gram-positive and/or Gram-negative bacteria and infectious diseases caused by and/or related to Gram-positive and/or Gram-negative bacteria. The invention further relates to the use of these compounds for preventing or eliminating biofilms.

  本发明涉及β-O/S/N脂肪酸及其衍生物，特别是如本文所述和定义的公式(I)化合物，以及它们的医药用途，包括用于治疗或预防细菌以及原生动物感染，尤其是治疗或预防革兰氏阳性菌和/或革兰氏阴性菌感染以及由革兰氏阳性菌和/或革兰氏阴性菌引起的传染病。本发明进一步涉及使用这些化合物来预防或消除生物膜。
• Thiirane and michael acceptor compounds and their medical use
  申请人：Ludwig-Maximilians-Universität München

  公开号：EP2607361A1

  公开（公告）日：2013-06-26

  The present invention relates to thiirane or Michael acceptor compounds, including the compounds of formula (I) as described and defined herein, and pharmaceutical compositions comprising these compounds, as well as their medical use, particularly their use in the treatment or prevention of a bacterial infection, including, e.g., an infection with multidrug-resistant Staphylococcus aureus.

  本发明涉及噻环丙烯或迈克尔受体化合物，包括本文描述和定义的式(I)化合物，以及包含这些化合物的药物组合物，以及它们的医药用途，特别是它们在治疗或预防细菌感染中的用途，例如对多重耐药金黄色葡萄球菌感染的用途。
• GAMMA-AAPEPTIDES WITH POTENT AND BROAD-SPECTRUM ANTIMICROBIAL ACTIVITY
  申请人：Cai Jianfeng

  公开号：US20150274782A1

  公开（公告）日：2015-10-01

  The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

  本发明涉及一种新型类别的抗微生物药物，称为γ-AA肽。当前发明提供了各种类别的γ-AA肽，例如线性γ-AA肽、环状γ-AA肽和脂质化γ-AA肽。本发明的γ-AA肽被设计为具有抗微生物活性，同时稳定且无毒。γ-AA肽似乎也不会导致被治疗微生物体内微生物产生抗药性。因此，所披露的γ-AA肽可用于治疗与病原微生物相关的各种医疗状况。
• BETA-LACTONES AS ANTIBACTERIAL AGENTS
  申请人：Sieber Stephan A.

  公开号：US20110196027A1

  公开（公告）日：2011-08-11

  The present invention relates to specific beta-lactone compounds and compositions thereof for the treatment of infections, such as, e.g., infections with bacteria or infections with protozoa, in particular infections with Gram-positive and/or Gram-negative bacteria and of infectious diseases caused by or related to Gram-positive and/or Gram-negative bacteria, and to the modulation of virulence of Gram-positive and/or Gram-negative bacteria or of protozoa by specific beta-lactone compounds. The invention further relates to the use of the compounds or compositions for preventing or eliminating biofilms.

  本发明涉及特定的β-内酰胺类化合物及其组合物，用于治疗感染，例如细菌感染或原虫感染，特别是革兰氏阳性和/或革兰氏阴性细菌感染以及由革兰氏阳性和/或革兰氏阴性细菌引起或相关的传染病，并且涉及通过特定的β-内酰胺类化合物调节革兰氏阳性和/或革兰氏阴性细菌或原虫的毒力。本发明还涉及使用这些化合物或组合物预防或消除生物膜。