1-(6-oxo-6,9-dihydro-1H-purin-2-yl)urea | 1133814-30-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 1-(6-oxo-6,9-dihydro-1H-purin-2-yl)urea
• 英文别名: (6-Oxo-1,7-dihydropurin-2-yl)urea；(6-oxo-1,7-dihydropurin-2-yl)urea
• CAS: 1133814-30-8
• 化学式: C₆H₆N₆O₂
• 分子量: 194.153
• InChiKey: MKGBVDDNOLVUGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  125
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-amine 在 盐酸 、 三光气 、 氨 、 sodium hydride 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 、 水 为溶剂， 反应 1.0h， 生成 1-(6-oxo-6,9-dihydro-1H-purin-2-yl)urea
  参考文献：
  名称：

  Efficient Synthesis of 2-Ureaguanines via the in situ Reactions of 2-Isocyanatopurines with Amines

  摘要：

  The synthesis of 2-ureaguanines is reported. The preparation involves a suitably protected intermediate, formation of a 2-isocyanatopurine and in situ trapping with a diverse range of amines followed by double deprotection. This is the first application of 2-isocyanatopurines for the synthesis of 2-ureaguanines.

  DOI：

  10.1055/s-0033-1338482

文献信息

• Integrated electrode and cell immobilization device equipped with the integrated electrode
  申请人：——

  公开号：US20040209352A1

  公开（公告）日：2004-10-21

  An integrated electrode capable of immobilizing an isolated cell and/or a cultured cell on the electrode without giving any damage to its cell membrane, and capable of detecting an electrophysiological activity of the immobilized cell with sufficient sensitivity is provided. An integrated electrode having a substrate equipped with at least one electric conductor, and a wiring part which leads an electrical signal out from the aforementioned electric conductor, in which the integrated electrode can detect an electrical signal resulting from an electrophysiological change of a cell immobilized on the surface of the aforementioned electric conductor, and at least a part of the surface of the aforementioned electric conductor is coated with a dielectric material, with the aforementioned dielectric material being a positively charged polymer material, and the aforementioned cell being an isolated cell and/or a cultured cell.

  本发明提供了一种集成电极，它能将离体细胞和/或培养细胞固定在电极上而不损伤其细胞膜，并能以足够的灵敏度检测被固定细胞的电生理活动。一种集成电极，其基板上装有至少一个电导体，以及一个将电信号从上述电导体引出的接线部分，其中集成电极可检测固定在上述电导体表面的细胞的电生理变化产生的电信号，上述电导体表面的至少一部分涂有介电材料，上述介电材料为带正电荷的聚合物材料，上述细胞为离体细胞和/或培养细胞。
• Efficient Synthesis of 2-Ureaguanines via the in situ Reactions of 2-Isocyanatopurines with Amines
  作者：Eric Marsault、Antoine Le Roux

  DOI：10.1055/s-0033-1338482

  日期：——

  The synthesis of 2-ureaguanines is reported. The preparation involves a suitably protected intermediate, formation of a 2-isocyanatopurine and in situ trapping with a diverse range of amines followed by double deprotection. This is the first application of 2-isocyanatopurines for the synthesis of 2-ureaguanines.