N-benzyl-N-(1'-phenylethyl)formamide | 71475-22-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl-N-(1'-phenylethyl)formamide
• 英文别名: N-Benzyl-N-(1-phenylethyl)formamid；N-benzyl-N-(1-phenylethyl)formamide
• CAS: 71475-22-4
• 化学式: C₁₆H₁₇NO
• 分子量: 239.317
• InChiKey: JUTKOVMEIVQLOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-benzyl-N-(1'-phenylethyl)formamide 在 硫酸 作用下， 以 乙醇 为溶剂， 生成 N-苄基-N-(1-苯基乙基)胺
  参考文献：
  名称：

  Phase-Transfer-CatalysedN-Alkylation ofN-Substituted Formamides; An Alternative Procedure for the Ritter Reaction

  摘要：

  DOI：

  10.1055/s-1979-28759
• 作为产物：
  描述：

  N-(1-苯基乙基)甲酰胺 、 氯化苄 生成 N-benzyl-N-(1'-phenylethyl)formamide
  参考文献：
  名称：

  Phase-Transfer-CatalysedN-Alkylation ofN-Substituted Formamides; An Alternative Procedure for the Ritter Reaction

  摘要：

  DOI：

  10.1055/s-1979-28759

文献信息

• Intramolecular and intermolecular Schmidt reactions of alkyl azides with aldehydes
  作者：Huey-Lih Lee、Jeffrey Aubé

  DOI：10.1016/j.tet.2007.05.079

  日期：2007.9

  Despite recent advances in the use of alkyl azides in ring expansion reactions of ketones, there has been little work done on the corresponding chemistry of aldehydes. In the present study, the Lewis acid-promoted reactions of alkyl azides with aldehydes were studied in both intermolecular and intramolecular contexts. The intramolecular reactions of azidoalkyl aldehydes in which the azide and carbonyl groups were separated by 2-5 carbons were examined. Although the examples having the shortest tether failed (3-azidopropanals), each of the other systems gave good yields of either NH-substituted lactams (resulting from hydride migration in the initially formed azidohydrin adduct) or formamides (alkyl migration). The product formed was dependent on the chain length of the starting azido aldehyde. The intermolecular reactions were less efficient, requiring TiCl4 promotion for even moderate yields, and in each case gave mixtures of products resulting from hydride and alkyl migration. (C) 2007 Elsevier Ltd. All rights reserved.
• GAJDA T.; KOZIARA A.; ZAWADSKI S.; ZWIERZAK A., SYNTHESIS, 1979, NO 7, 549-552
  作者：GAJDA T.、 KOZIARA A.、 ZAWADSKI S.、 ZWIERZAK A.

  DOI：——

  日期：——
• Phase-Transfer-Catalysed<i>N</i>-Alkylation of<i>N</i>-Substituted Formamides; An Alternative Procedure for the Ritter Reaction
  作者：Tadeusz Gajda、Anna Koziara、Stefan Zawadzki、Andrzej Zweirzak

  DOI：10.1055/s-1979-28759

  日期：——