2-Methyl-4-pyren-1-ylbut-2-enoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: 2-Methyl-4-pyren-1-ylbut-2-enoic acid
• 英文别名: 2-methyl-4-pyren-1-ylbut-2-enoic acid
• 化学式: C₂₁H₁₆O₂
• 分子量: 300.3
• InChiKey: YUGAKUPPDDHEHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Delivery device for a controlled drug release of an active agent into the posterior section of the eye
  申请人：SurModics, Inc.

  公开号：EP1671624A1

  公开（公告）日：2006-06-21

  The invention provides a controlled release bioactive agent delivery device for delivery of bioactive agent to a posterior segment of an eye, the device comprising a body member formed of a material having a cross-section, the body member having a direction of extension, a longitudinal axis along the direction of extension, and two or more deviations from the direction of extension, wherein the deviations are spaced from each other a distance that is equal to or greater than the cross-section of the material forming the body member; and a polymeric coated composition in contact with the body member, the polymeric coated composition comprising a first polymer, a second polymer, and a bioactive agent.

  本发明提供了一种用于向眼球后段输送生物活性剂的控释生物活性剂输送装置，该装置包括由具有横截面的材料形成的主体构件，主体构件具有延伸方向、沿延伸方向的纵向轴线以及与延伸方向的两个或多个偏差，其中偏差彼此间隔的距离等于或大于形成主体构件的材料的横截面；与本体部件接触的聚合物涂层组合物，聚合物涂层组合物包括第一聚合物、第二聚合物和生物活性剂。
• Method and system for providing bioactive agent release coating
  申请人：——

  公开号：US20020188037A1

  公开（公告）日：2002-12-12

  A coating composition, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a combination of a first polymer component such as polyalyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

  一种涂层组合物，以及在可控湿度条件下使用这种组合物的方法，用于在设备表面进行涂层，以控制和/或提高其在水性体系中释放生物活性剂的能力。该涂层组合物尤其适用于在输送和/或使用过程中会发生明显弯曲和/或膨胀的医疗器械，如支架和导管。该组合物包括生物活性剂与第一种聚合物成分（如聚丙烯酸丙烯酰（甲基）酯、聚丙烯酸芳基（甲基）酯、聚丙烯酸芳烷基（甲基）酯或聚芳氧基烷基（甲基）丙烯酸酯）和第二种聚合物成分（如聚（乙烯-乙酸乙烯酯））的组合。
• Bioactive agent release coating with aromatic poly(meth)acrylates
  申请人：——

  公开号：US20030232087A1

  公开（公告）日：2003-12-18

  A coating composition, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a combination of a first polymer component such as polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

  一种涂层组合物，以及在可控湿度条件下使用这种组合物的方法，用于在设备表面进行涂层，以控制和/或提高其在水性体系中释放生物活性剂的能力。该涂层组合物尤其适用于在输送和/或使用过程中会发生明显弯曲和/或膨胀的医疗器械，如支架和导管。该组合物包括生物活性剂与第一种聚合物成分（如聚芳基（甲基）丙烯酸酯、聚芳基（甲基）丙烯酸酯或聚芳氧基烷基（甲基）丙烯酸酯）和第二种聚合物成分（如聚（乙烯-乙酸乙烯酯））的组合。
• Bioactive agent release coating and controlled humidity method
  申请人：——

  公开号：US20030232122A1

  公开（公告）日：2003-12-18

  A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

  一种单组分或多组分系统形式的涂层组合物，以及在可控湿度条件下使用这种组合物的方法，用于涂覆设备表面，以控制和/或提高其在水性体系中释放生物活性剂的能力。该涂层组合物尤其适用于在输送和/或使用过程中会发生明显弯曲和/或膨胀的医疗器械，如支架和导管。该组合物包括与聚烷基（甲基）丙烯酸酯、聚芳基（甲基）丙烯酸酯、聚芳基（甲基）丙烯酸酯或聚芳氧基烷基（甲基）丙烯酸酯等第一聚合物成分和聚乙烯-醋酸乙烯酯等第二聚合物成分结合使用的生物活性剂。
• Barriers for polymeric coatings
  申请人：——

  公开号：US20040111144A1

  公开（公告）日：2004-06-10

  A barrier adapted to be positioned between a first surface provided in the form of a polymeric, bioactive agent-containing coating upon a medical device, and a second surface provided by another material positioned in apposition, and preferably moveable apposition, to the first surface. The barrier, as provided by block copolymers or photoderivatized polymers, provides protection to the polymeric composition from mechanical damage and/or delamination during fabrication, storage, delivery or deployment, and/or residence of the device within the body. A combination that includes a medical device, such as a stent, and another device, such as a surrounding sheath or internal expandable balloon, between which is positioned a barrier of the type described.

  一种阻隔物，可设置在医疗器械上以含生物活性剂的聚合物涂层形式提供的第一表面与由另一种材料提供的第二表面之间，该第二表面与第一表面贴合，最好是可移动贴合。阻隔层由嵌段共聚物或光钝化聚合物提供，可保护聚合物组合物在制造、储存、输送或部署和/或设备在体内停留期间免受机械损伤和/或分层。包括支架等医疗装置和周围鞘或内部可膨胀球囊等另一装置的组合，在这些装置之间设置了所述类型的屏障。