10-Hexadecyl-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 10-Hexadecyl-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazole
• 英文别名: 10-hexadecyl-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazole
• 化学式: C₂₆H₄₃N₃
• 分子量: 397.6
• InChiKey: MWLSLHMBTORCGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  29
• 可旋转键数：
  15
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  18.8
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Methods and Compositions for Treating Alzheimer's Disease
  申请人：Worley Paul

  公开号：US20110183942A1

  公开（公告）日：2011-07-28

  A method is disclosed for inhibiting the build-up of amyloid plaques in the brain of a patient with at least one risk factor for, or a diagnosis of, Alzheimer's Disease by administering to the patient an amount of one or more compounds effective to inhibit the phosphorylative activity of eEF2K, thereby inhibiting amyloid plaque deposition.
• NOVEL COMPOUNDS FOR INHIBITING EEF-2 KINASE ACTIVITY
  申请人：Ryazanov Alexey G.

  公开号：US20120178769A1

  公开（公告）日：2012-07-12

  The present invention discloses novel compounds for inhibiting eEF2 kinase and methods of use thereof.
• [EN] NOVEL COMPOUNDS FOR INHIBITING EEF2 KINASE ACTIVITY<br/>[FR] NOUVEAUX COMPOSÉS POUR INHIBER L'ACTIVITÉ EEF2 KINASE
  申请人：UNIV NEW JERSEY MED

  公开号：WO2011009010A1

  公开（公告）日：2011-01-20

  The present invention discloses novel compounds for inhibiting eEF2 kinase and methods of use thereof.